Recombinant Mouse Fus Protein, Myc/DDK-tagged

• Cat.No.: Fus-3107M
• Product Overview: Purified recombinant protein of mouse full-length fused in sarcoma (Fus), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response. Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing. Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay. Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair. In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 53.1 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Fus fused in sarcoma [ Mus musculus (house mouse) ]
• Official Symbol: Fus
• Synonyms: FUS; fusion, derived from t(12;16) malignant liposarcoma (human); RNA-binding protein FUS; hnRNP P2; pigpen protein; protein pigpen; translocated in liposarcoma; Tls; Fus1; D430004D17Rik; D930039C12Rik
• Gene ID: 233908
• mRNA Refseq: NM_139149
• Protein Refseq: NP_631888
• UniProt ID: P56959