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Recombinant Mouse Grk6 Protein, Myc/DDK-tagged

Cat.No. : Grk6-3312M
Product Overview : Purified recombinant protein of mouse full-length G protein-coupled receptor kinase 6 (Grk6), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Specifically phosphorylates the activated forms of G protein-coupled receptors. Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their desensitization. Seems to be involved in the desensitization of D2-like dopamine receptors in striatum and chemokine receptor CXCR4 which is critical for CXCL12-induced cell chemotaxis. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro).
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 67.1 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Grk6 G protein-coupled receptor kinase 6 [ Mus musculus (house mouse) ]
Official Symbol : Grk6
Synonyms : GRK6; G protein-coupled receptor kinase 6; g protein-coupled receptor kinase GRK6; Gprk6
Gene ID : 26385
mRNA Refseq : NM_001112711
Protein Refseq : NP_001106182
UniProt ID : O70293

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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