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Recombinant Mouse IL13RA1 protein, Fc-tagged

Cat.No. : IL13RA1-395M
Product Overview : Recombinant Mouse IL13RA1 protein (Ala26-Thr340), fused to human IgG1 Fc tag at C-terminus, was expressed in human 293 cells (HEK293).
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Description : Interleukin 13 receptor, alpha 1 is also known as IL13RA1, NR4 and CD213A1 (cluster of differentiation 213A1), The IL13 Rα1 cDNA encodes a 427 amino acid (aa) residue precursor protein with a putative 21 aa residue signal peptide, a 324 aa residue extracellular domain, a 23 aa residue transmembrane region and a 59 aa residue cytoplasmic tail. Human and mouseIL13Rα1 share 76% aa sequence identity. IL13RA1 is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4.
Source : HEK293
Species : Mouse
Tag : human IgG1 Fc
Form : Lyophilized from 0.22 um filtered solution in Tris with Glycine, Arginine and NaCl, pH7.5, 10% trehalose.
Molecular Mass : The protein has a calculated MW of 62.7 kDa. The protein migrates as 67-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Protein length : 315
Endotoxin : Less than 1.0 EU per ug by the LAL method.
Purity : >95% as determined by SDS-PAGE.
Storage : For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
-20 centigrade to -70 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
Reconstitution : It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.
Gene Name : IL13RA1
Official Symbol : IL13RA1
Synonyms : IL13RA1; interleukin 13 receptor, alpha 1; interleukin-13 receptor subunit alpha-1; IL-13RA1; IL-13R-alpha-1; IL-13R subunit alpha-1; novel cytokine receptor 4; IL-13 receptor subunit alpha-1; interleukin-13-binding protein; NR4; Il13ra; CD213a1; AI882074; IL-13r[a]
Gene ID : 16164
mRNA Refseq : NM_133990
Protein Refseq : NP_598751
UniProt ID : Q8BNM4

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (10)

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What techniques determine IL13RA1 expression levels in different cell types? 12/05/2022

Techniques quantify IL13RA1 expression across diverse cell types.

What experimental strategies discern IL13RA1 isoforms and their functions? 10/04/2021

Strategies distinguish IL13RA1 isoforms and their roles.

Could you elaborate on the use of RNA-seq in profiling IL13RA1-regulated gene expression? 04/01/2021

RNA-seq profiles IL13RA1's influence on gene expression.

What are the advantages of using CRISPR/Cas9 to knockout IL13RA1 expression? 05/10/2020

CRISPR/Cas9 knockout clarifies IL13RA1's functional impact.

How do siRNA knockdown experiments validate IL13RA1's involvement in specific pathways? 03/08/2020

siRNA knockdown validates IL13RA1's pathway involvement.

Can you explain the role of co-immunoprecipitation in identifying IL13RA1 interaction partners? 01/17/2020

Co-immunoprecipitation identifies IL13RA1 interactors.

How does immunofluorescence microscopy visualize IL13RA1 localization within cells? 05/22/2019

Immunofluorescence microscopy visualizes intracellular IL13RA1 localization.

How does surface plasmon resonance (SPR) elucidate IL13RA1 binding kinetics? 10/08/2018

SPR elucidates IL13RA1 binding kinetics with precision.

Can you describe how surface biotinylation studies reveal IL13RA1 membrane localization? 09/25/2018

Surface biotinylation shows IL13RA1 membrane distribution.

How do fluorescence-based assays assess IL13RA1 internalization upon ligand binding? 06/19/2018

Fluorescence assays monitor IL13RA1 internalization upon ligand binding.

Customer Reviews (3)

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Reviews
01/10/2022

    High solubility.

    01/17/2019

      Potent in anti-allergic assays.

      04/26/2018

        Suitable for ELISA.

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