Recombinant Mouse Il1rap Protein, Myc/DDK-tagged
Cat.No. : | Il1rap-3508M |
Product Overview : | Purified recombinant protein of mouse full-length interleukin 1 receptor accessory protein (Il1rap), with C-terminal MYC/DDK tag, expressed in HEK293T cells. |
- Specification
- Gene Information
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Description : | Coreceptor for IL1RL2 in the IL-36 signaling system. Coreceptor with IL1R1 in the IL-1 signaling system. Associates with IL1R1 bound to IL1B to form the high affinity interleukin-1 receptor complex which mediates interleukin-1-dependent activation of NF-kappa-B and other pathways. Signaling involves the recruitment of adapter molecules such as TOLLIP, MYD88, and IRAK1 or IRAK2 via the respective TIR domains of the receptor/coreceptor subunits. Recruits TOLLIP to the signaling complex. Does not bind to interleukin-1 alone; binding of IL1RN to IL1R1, prevents its association with IL1R1 to form a signaling complex. The cellular response is modulated through a non-signaling association with the membrane IL1R2 decoy receptor. Secreted forms (isoforms 2 and 3) associate with secreted ligand-bound IL1R2 and increase the affinity of secreted IL1R2 for IL1B; this complex formation may be the dominant mechanism for neutralization of IL1B by secreted/soluble receptors. Coreceptor for IL1RL1 in the IL-33 signaling system. Can bidirectionally induce pre- and postsynaptic differentiation of neurons by trans-synaptically binding to PTPRD. May play a role in IL1B-mediated costimulation of IFNG production from T-helper 1 (Th1) cells. |
Source : | HEK293T |
Species : | Mouse |
Tag : | Myc/DDK |
Molecular Mass : | 41.6 kDa |
Purity : | > 80% as determined by SDS-PAGE and Coomassie blue staining |
Stability : | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
Storage : | Store at -80 centigrade after receiving vials. |
Concentration : | >50 μg/mL as determined by microplate BCA method |
Storage Buffer : | 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol. |
Gene Name : | Il1rap interleukin 1 receptor accessory protein [ Mus musculus (house mouse) ] |
Official Symbol : | Il1rap |
Synonyms : | IL1RAP; interleukin 1 receptor accessory protein; interleukin-1 receptor accessory protein; IL-1 receptor accessory protein; AI255955; AV239853; IL-1RAcP; 6430709H04Rik |
Gene ID : | 16180 |
mRNA Refseq : | NM_134103 |
Protein Refseq : | NP_598864 |
UniProt ID : | Q61730 |
Products Types
◆ Recombinant Protein | ||
IL1RAP-2062R | Recombinant Rhesus Macaque IL1RAP Protein, His (Fc)-Avi-tagged | +Inquiry |
Il1rap-443M | Recombinant Mouse IL1RAP Protein, His-tagged | +Inquiry |
IL1RAP-356H | Recombinant Human IL1RAP Protein, MYC/DDK-tagged, C13 and N15-labeled | +Inquiry |
IL1RAP-304H | Recombinant Human IL1RAP Protein, His-tagged | +Inquiry |
IL1RAP-305H | Recombinant Human IL1RAP Protein, Fc-tagged | +Inquiry |
◆ Lysates | ||
IL1RAP-2730HCL | Recombinant Human IL1RAP cell lysate | +Inquiry |
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (10)
Ask a questionSingle-cell RNA sequencing and proteomics unveil IL1RAP's interactions in networks.
Genome mapping and assays unveil IL1RAP's epigenetic control.
Innovative methods clarify IL1RAP's distribution diversity, revealing its functional adaptability.
Advanced imaging and genetic models illuminate IL1RAP's immune role.
Simulations and experiments reveal IL1RAP's interaction details.
Engineered cell models shed light on IL1RAP's role in inflammation.
Structural techniques provide insights into IL1RAP's ligand interactions.
Strategies uncover post-translational effects on IL1RAP's signaling.
Organ-on-chip tech explores IL1RAP's impact on pathways.
Novel techniques decode IL1RAP isoforms, exposing their influence on cell responses.
Customer Reviews (3)
Write a reviewHigh solubility.
Good for intracellular staining.
Effective in apoptosis assays.
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