IL1RAP Protein

IL1RAP

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IL1RAP

Official Full Name interleukin 1 receptor accessory protein
Background Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
Synonyms IL1RAP; interleukin 1 receptor accessory protein; IL1R3; C3orf13; IL-1RAcP; IL-1R3; interleukin-1 receptor 3; interleukin-1 receptor accessory protein beta; OTTHUMP00000209487; OTTHUMP00000209488; OTTHUMP00000209489; OTTHUMP00000209490; OTTHUMP00000209491; OTTHUMP00000209492; IL-1 receptor accessory protein; OTTHUMP00000209493; FLJ37788; interleukin-1 receptor accessory protein; OTTHUMP00000209485; OTTHUMP00000209486; IL-1R-3
    • Species :
    • Cynomolgus
    • Human
    • Macaca mulatta (Rhesus macaque)
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • E.coli expression system
    • HEK293
    • HEK293T
    • Human Cell
    • Human Cells
    • Mammalian Cell
    • Sf21 Insect Cell
    • Tag :
    • C-Myc/DDK
    • DYKDDDDK
    • Fc
    • Fc/His
    • His
    • hFc
    • T7
    • His-Avi
    • human
    • IgG1
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human IL1RAP-628H Recombinant Human IL1RAP, Fc-tagged, Biotinylated Human Cell Fc
    Human IL1RAP-14176H Recombinant Human IL1RAP, His-tagged E.coli His
    Human IL1RAP-1638H Recombinant Human Interleukin 1 Receptor Accessory Protein-Like 1 Sf21 Insect Cell N/A
    Human IL1RAP-175H Recombinant Human IL1RAP, Fc-His tagged Human Cell Fc/His
    Human IL1RAP-215H Recombinant Human IL1RAP Protein, His-tagged HEK293 His
    Human IL1RAP-2256H Recombinant Human IL1RAP protein, His-tagged HEK293 His
    Human IL1RAP-627H Recombinant Human IL1RAP protein, Fc-tagged HEK293 human/IgG1/Fc
    Rhesus Macaque IL1RAP-2241R Recombinant Rhesus monkey IL1RAP Protein, His-tagged Mammalian Cell His
    Human IL1RAP-2730HCL Recombinant Human IL1RAP cell lysate Human Cell N/A
    Cynomolgus IL1RAP-066C Recombinant Cynomolgus IL1RAP protein, His-tagged HEK293 His
    Cynomolgus IL1RAP-138C Recombinant Cynomolgus IL1RAP protein, hFc-tagged HEK293 hFc
    Human IL1RAP-151H Recombinant Human IL1RAP Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
    Human IL1RAP-175HAF488 Recombinant Human IL1RAP Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His
    Human IL1RAP-175HAF555 Recombinant Human IL1RAP Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His
    Human IL1RAP-175HAF647 Recombinant Human IL1RAP Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His
    Human IL1RAP-175HF Recombinant Human IL1RAP Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His
    Human IL1RAP-25H Recombinant Human IL1RAP Protein, His-tagged HEK293 His
    Human IL1RAP-627HAF488 Recombinant Human IL1RAP Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc
    Human IL1RAP-627HAF555 Recombinant Human IL1RAP Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc
    Human IL1RAP-627HAF647 Recombinant Human IL1RAP Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc
    Human IL1RAP-627HF Recombinant Human IL1RAP Protein, hFc-tagged, FITC conjugated HEK293 hFc
    Macaca mulatta (Rhesus macaque) RFL14823MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) Interleukin-1 Receptor Accessory Protein(Il1Rap) Protein, His-Tagged E.coli expression system His
    Human IL1RAP-093H Recombinant Human IL1RAP protein, His-Avi-tagged HEK293 His-Avi
    Human IL1RAP-093HB Recombinant Human IL1RAP protein, His-Avi-tagged, Biotinylated HEK293 His-Avi
    Human IL1RAP-175HA Recombinant Human IL1RAP protein, Fc-His-tagged, APC labeled HEK293 Fc/His
    Human IL1RAP-175HP Recombinant Human IL1RAP protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
    Human IL1RAP-1820H Recombinant Human IL1RAP Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human IL1RAP-356H Recombinant Human IL1RAP Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
    Human IL1RAP-627HA Recombinant Human IL1RAP protein, Fc-tagged, APC labeled HEK293 Fc
    Human IL1RAP-627HP Recombinant Human IL1RAP protein, Fc-tagged, R-PE labeled HEK293 Fc
    Mouse Il1rap-1576M Recombinant Mouse Il1rap protein, His & T7-tagged E.coli His/T7
    Mouse Il1rap-3508M Recombinant Mouse Il1rap Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Mouse Il1rap-443M Recombinant Mouse IL1RAP Protein, His-tagged HEK293 His
    Mouse Il1rap-444M Recombinant Mouse IL1RAP Protein, Fc-tagged HEK293 Fc

    IL1RAP involved in several pathways and played different roles in them. We selected most pathways IL1RAP participated on our site, such as Cytokine-cytokine receptor interaction, Apoptosis, Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1RAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction Ifna15; IFNW1; GM1987; IFNA10; VEGFA; TGFBR1B; TNFRSF12A; CXCR4A; TNFRSF11B; ACVR1L
    Apoptosis BNIP3LB; CASP6L2; CASP8; LMNB1; Gzmg; NTRK1; IL3RA; HIST1H1E; PRKAR2B; BNIP3L
    Inflammatory mediator regulation of TRP channels TRPV4; MAPK11; MAP2K6; SRC; BDKRB1; CYP2C38; ASIC2; PLCB4; TRPV2; IL1R1

    IL1RAP has several biochemical functions, for example, interleukin-1 receptor activity, interleukin-1 receptor binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1RAP itself. We selected most functions IL1RAP had, and list some proteins which have the same functions with IL1RAP. You can find most of the proteins on our site.

    Function Related Protein
    interleukin-1 receptor activity IL18R1; IL1RAPL2; IL1RL2; IL1R1; IL1RAPL1A; IL1R2; IL1RL1; IL1RAP
    interleukin-1 receptor binding IL1A; IRAK1; TLR9; IL1RN; TRIP6; IL36A; IRAK4; IL36B; IL1F10; IL37
    signal transducer activity OPN4XA; MRGPRB8; TAS2R129; GNG2; TMTOPS3B; PDCD1; TAAR8A; CC2D1A; OLFR15; VMN1R47

    IL1RAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1RAP here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1RAP.

    IL1B; IL1R2; IL1R1; SMAD2; TICAM2; PRPF40A; MC4R; PRKCI; KPNA1; CCNI

    Askmyr, M; Agerstam, H; et al. Selective killing of candidate AML stem cells by antibody targeting of IL1RAP. BLOOD 121:3709-3713(2013).
    Jaras, M; Johnels, P; et al. Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:16280-16285(2010).
    Jaras, M; Johnels, P; et al. ISOLATION AND KILLING OF CANDIDATE CML STEM CELLS BY ANTIBODY TARGETING OF IL1RAP. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 95:242-242(2010).

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