IL1RAP
-
Official Full Name
interleukin 1 receptor accessory protein
-
Overview
Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress. -
Synonyms
IL1RAP; interleukin 1 receptor accessory protein; IL1R3; C3orf13; IL-1RAcP; IL-1R3; interleukin-1 receptor 3; interleukin-1 receptor accessory protein beta; OTTHUMP00000209487; OTTHUMP00000209488; OTTHUMP00000209489; OTTHUMP00000209490; OTTHUMP00000209491; OTTHUMP00000209492; IL-1 receptor accessory protein; OTTHUMP00000209493; FLJ37788; interleukin-1 receptor accessory protein; OTTHUMP00000209485; OTTHUMP00000209486; IL-1R-3;
- Recombinant Proteins
- Cell & Tissue Lysates
- Protein Pre-coupled Magnetic Beads
- Cynomolgus
- Human
- Macaca mulatta (Rhesus macaque)
- Mouse
- Rat
- Rhesus Macaque
- Rhesus monkey
- E.coli
- E.coli expression system
- HEK293
- HEK293T
- Human Cell
- Human Cells
- Mammalian cells
- Sf21 Insect Cell
- C
- His
- Avi
- Fc
- Flag
- Myc
- T7
- DDK
- Non
- Involved Pathway
- Protein Function
- Interacting Protein
- Other Resource
IL1RAP involved in several pathways and played different roles in them. We selected most pathways IL1RAP participated on our site, such as Cytokine-cytokine receptor interaction, Apoptosis, Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1RAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Cytokine-cytokine receptor interaction | IFNA1;ACVR1BA;ACVR1B;CTF1;INHBE;LIF;CRLF2;IFNK;IL23 |
| Apoptosis | DAPK1;BMX;HMGB2A;PTBP3;PRKAR1AB;PRKACA;CASP2;LMNB1;IL1A |
| Inflammatory mediator regulation of TRP channels | PRKACA;CAMK2D;CALML5;HTR2A;PLCG2;TRPM8;PRKCA;PIK3R3;ASIC5 |
IL1RAP has several biochemical functions, for example, interleukin-1 receptor activity, interleukin-1 receptor binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1RAP itself. We selected most functions IL1RAP had, and list some proteins which have the same functions with IL1RAP. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| interleukin-1 receptor activity | IL1RL1;IL18R1;IL1RAPL2;IL1RAPL1A;IL1RAP;IL1R1;IL1RL2;IL1R2 |
| interleukin-1 receptor binding | IL36RN;IL36A;IL1B;IL1RN;IL1RAP;IL1F10;IRAK1;IL36G;TLR9 |
| signal transducer activity | OLFR998;TAAR7F;STMN1;LGALS1;OLFR478;TAAR4;MRGPRB1;S100A9;TAAR2 |
IL1RAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1RAP here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1RAP.
IL1B; IL1R2; IL1R1; SMAD2; TICAM2; PRPF40A; MC4R; PRKCI; KPNA1; CCNI
Gene Family
Research Area
Related articles
- Reviews
- Q&As
Customer Reviews (3)
Write a reviewHigh solubility.
Good for intracellular staining.
Effective in apoptosis assays.
Q&As (10)
Ask a questionSingle-cell RNA sequencing and proteomics unveil IL1RAP's interactions in networks.
Genome mapping and assays unveil IL1RAP's epigenetic control.
Innovative methods clarify IL1RAP's distribution diversity, revealing its functional adaptability.
Advanced imaging and genetic models illuminate IL1RAP's immune role.
Simulations and experiments reveal IL1RAP's interaction details.
Engineered cell models shed light on IL1RAP's role in inflammation.
Structural techniques provide insights into IL1RAP's ligand interactions.
Strategies uncover post-translational effects on IL1RAP's signaling.
Organ-on-chip tech explores IL1RAP's impact on pathways.
Novel techniques decode IL1RAP isoforms, exposing their influence on cell responses.
Ask a Question for All IL1RAP Products
Required fields are marked with *
My Review for All IL1RAP Products
Required fields are marked with *
