IL1RAP

  • Official Full Name

    interleukin 1 receptor accessory protein

  • Overview

    Interleukin 1 induces synthesis of acute phase and proinflammatory proteins during infection, tissue damage, or stress, by forming a complex at the cell membrane with an interleukin 1 receptor and an accessory protein. This gene encodes the interleukin 1 receptor accessory protein. The protein is a necessary part of the interleukin 1 receptor complex which initiates signalling events that result in the activation of interleukin 1-responsive genes. Alternative splicing of this gene results in two transcript variants encoding two different isoforms, one membrane-bound and one soluble. The ratio of soluble to membrane-bound forms increases during acute-phase induction or stress.
  • Synonyms

    IL1RAP; interleukin 1 receptor accessory protein; IL1R3; C3orf13; IL-1RAcP; IL-1R3; interleukin-1 receptor 3; interleukin-1 receptor accessory protein beta; OTTHUMP00000209487; OTTHUMP00000209488; OTTHUMP00000209489; OTTHUMP00000209490; OTTHUMP00000209491; OTTHUMP00000209492; IL-1 receptor accessory protein; OTTHUMP00000209493; FLJ37788; interleukin-1 receptor accessory protein; OTTHUMP00000209485; OTTHUMP00000209486; IL-1R-3;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Cynomolgus
  • Human
  • Macaca mulatta (Rhesus macaque)
  • Mouse
  • Rhesus Macaque
  • Rhesus monkey
  • E.coli
  • E.coli expression system
  • HEK293
  • HEK293T
  • Human Cell
  • Human Cells
  • Mammalian cells
  • Sf21 Insect Cell
  • C
  • hFc
  • His
  • Myc
  • DDK
  • DYKDDDDK
  • Fc
  • Avi
  • Fc|His
  • His (Fc)
  • His|T7
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human IL1RAP-628H Active Recombinant Human IL1RAP, Fc-tagged, Biotinylated Human Cell Fc
Human IL1RAP-1638H Recombinant Human Interleukin 1 Receptor Accessory Protein-Like 1 Sf21 Insect Cell N/A
Human IL1RAP-2256H Recombinant Human IL1RAP protein, His-tagged HEK293 His Met 1-Glu 359
Human IL1RAP-175H Recombinant Human IL1RAP, Fc-His tagged Human Cell Fc/His
Human IL1RAP-627H Recombinant Human IL1RAP protein, hFc-tagged HEK293 C-hFc Ser21-Glu359
Human IL1RAP-14176H Recombinant Human IL1RAP, His-tagged E.coli His 21-356a.a.
Human IL1RAP-215H Recombinant Human IL1RAP Protein, His-tagged HEK293 His
Human IL1RAP-2730HCL Recombinant Human IL1RAP cell lysate Human Cell N/A
Human IL1RAP-175HP Recombinant Human IL1RAP protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
Human IL1RAP-175HF Recombinant Human IL1RAP Protein, Fc/His-tagged, FITC conjugated HEK293 Fc/His 586
Human IL1RAP-093H Recombinant Human IL1RAP protein, His-Avi-tagged HEK293 His-Avi Ser21-Glu359
Human IL1RAP-304H Recombinant Human IL1RAP Protein, His-tagged HEK293 His 570
Human IL1RAP-151H Recombinant Human IL1RAP Protein, DYKDDDDK-tagged Human Cells DYKDDDDK
Human IL1RAP-25H Recombinant Human IL1RAP Protein, His-tagged HEK293 His
Human IL1RAP-356H Recombinant Human IL1RAP Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 C-Myc/DDK
Human IL1RAP-0266H Active Recombinant Human IL1RAP protein, Fc-tagged HEK293 Fc Ser21-Glu359
Human IL1RAP-175HAF555 Recombinant Human IL1RAP Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Fc/His 586
Human IL1RAP-1306H Recombinant Human IL1RAP protein, Fc & Avi-tagged HEK293 Fc/Avi Ser 21 - Glu 359
Human IL1RAP-175HAF488 Recombinant Human IL1RAP Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Fc/His 586
Human IL1RAP-627HP Recombinant Human IL1RAP protein, Fc-tagged, R-PE labeled HEK293 Fc
Human IL1RAP-627HAF647 Recombinant Human IL1RAP Protein, hFc-tagged, Alexa Fluor 647 conjugated HEK293 hFc Ser21-Glu359
Human IL1RAP-1820H Recombinant Human IL1RAP Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human IL1RAP-627HAF488 Recombinant Human IL1RAP Protein, hFc-tagged, Alexa Fluor 488 conjugated HEK293 hFc Ser21-Glu359
Human IL1RAP-093HB Active Recombinant Human IL1RAP protein, His-Avi-tagged, Biotinylated HEK293 His-Avi Ser21-Glu359
Human IL1RAP-627HF Recombinant Human IL1RAP Protein, hFc-tagged, FITC conjugated HEK293 hFc Ser21-Glu359
Human IL1RAP-175HA Recombinant Human IL1RAP protein, Fc-His-tagged, APC labeled HEK293 Fc/His
Human IL1RAP-0263H Active Recombinant Human IL1RAP protein, His-tagged, FITC-Labeled HEK293 His 21Ser-359Glu
Human IL1RAP-627HAF555 Recombinant Human IL1RAP Protein, hFc-tagged, Alexa Fluor 555 conjugated HEK293 hFc Ser21-Glu359
Human IL1RAP-305H Recombinant Human IL1RAP Protein, Fc-tagged HEK293 Fc 570
Human IL1RAP-627HA Recombinant Human IL1RAP protein, Fc-tagged, APC labeled HEK293 Fc
Human IL1RAP-0264H Active Recombinant Human IL1RAP protein, Fc-Avi-tagged, Biotinylated HEK293 Fc-Avi Ser21-Glu359
Human IL1RAP-175HAF647 Recombinant Human IL1RAP Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Fc/His 586
Human IL1RAP-2832H Recombinant Human IL1RAP Protein (Gly65-Asn249), N-His tagged E.coli N-His Gly65-Asn249
Human IL1RAP-4268H Recombinant Human IL1RAP Protein (Met1-Glu359), C-His tagged Mammalian cells C-His Met1-Glu359
Mouse Il1rap-3508M Recombinant Mouse Il1rap Protein, Myc/DDK-tagged HEK293T Myc/DDK
Mouse IL1RAP-0265M Recombinant Mouse IL1RAP protein, His-tagged HEK293 His Ser21-Glu359
Mouse Il1rap-1576M Recombinant Mouse Il1rap protein, His & T7-tagged E.coli His/T7 Ser21~Thr367 (Accession # Q61730)
Mouse Il1rap-443M Recombinant Mouse IL1RAP Protein, His-tagged HEK293 His Met1-Lys350
Mouse Il1rap-444M Recombinant Mouse IL1RAP Protein, Fc-tagged HEK293 Fc
Rhesus monkey IL1RAP-2241R Recombinant Rhesus monkey IL1RAP protein, His-tagged HEK293 His Met1-Glu359
Cynomolgus IL1RAP-066C Active Recombinant Cynomolgus IL1RAP protein, His-tagged HEK293 His Ser21-Glu359
Cynomolgus IL1RAP-138C Recombinant Cynomolgus IL1RAP protein, hFc-tagged HEK293 hFc Met1-Glu359
Macaca mulatta (Rhesus macaque) RFL14823MF Recombinant Full Length Macaca Mulatta (Rhesus Macaque) Interleukin-1 Receptor Accessory Protein(Il1Rap) Protein, His-Tagged E.coli expression system His Full Length (21-570)
Rhesus Macaque IL1RAP-2062R-B Recombinant Rhesus Macaque IL1RAP Protein Pre-coupled Magnetic Beads HEK293
Rhesus Macaque IL1RAP-2062R Recombinant Rhesus Macaque IL1RAP Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource

IL1RAP involved in several pathways and played different roles in them. We selected most pathways IL1RAP participated on our site, such as Cytokine-cytokine receptor interaction, Apoptosis, Inflammatory mediator regulation of TRP channels, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1RAP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Cytokine-cytokine receptor interactionIL17RB;TGFBR1B;CCL28;TNFRSF11B;IFNA4;GDF5;KITLGB;XCL2;CXCL12A
ApoptosisPRKAR2B;CASP7;ENDOG;PRKACG;TNFRSF10B;IL3;OCLN;TNF;STK24B
Inflammatory mediator regulation of TRP channelsPPP1CC;PIK3R5;TRPV3;CYP2C55;PLA2G4D;PLCB3;HRH1;CALML5;PLA2G4F

IL1RAP has several biochemical functions, for example, interleukin-1 receptor activity, interleukin-1 receptor binding, signal transducer activity. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1RAP itself. We selected most functions IL1RAP had, and list some proteins which have the same functions with IL1RAP. You can find most of the proteins on our site.

Function Related Protein
interleukin-1 receptor activityIL1R2;IL1RAP;IL1RAPL2;IL1RAPL1A;IL1R1;IL1RL2;IL1RL1;IL18R1
interleukin-1 receptor bindingIL1RAP;IL36B;IL1A;TLR9;IL36G;IRAK4;IRAK1;IL36A;Il1f6
signal transducer activityPTK2BB;PTGER1B;OPN1MW1;GNA13A;GNGT2;TICAM2;OLFR507;OLFR491;F2RL2

IL1RAP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1RAP here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1RAP.

IL1B; IL1R2; IL1R1; SMAD2; TICAM2; PRPF40A; MC4R; PRKCI; KPNA1; CCNI

Gene Family

IL

Research Area

Related articles

Askmyr, M; Agerstam, H; et al. Selective killing of candidate AML stem cells by antibody targeting of IL1RAP. BLOOD 121:3709-3713(2013).
Jaras, M; Johnels, P; et al. Isolation and killing of candidate chronic myeloid leukemia stem cells by antibody targeting of IL-1 receptor accessory protein. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 107:16280-16285(2010).
Jaras, M; Johnels, P; et al. ISOLATION AND KILLING OF CANDIDATE CML STEM CELLS BY ANTIBODY TARGETING OF IL1RAP. HAEMATOLOGICA-THE HEMATOLOGY JOURNAL 95:242-242(2010).
  • Q&As
  • Reviews

Q&As (10)

Ask a question
How can single-cell RNA sequencing and proteomics uncover IL1RAP's interactions with immune receptors within complex networks? 02/11/2021

Single-cell RNA sequencing and proteomics unveil IL1RAP's interactions in networks.

Can genome-wide mapping and functional assays reveal the epigenetic regulation and context-specific expression of the IL1RAP gene? 02/19/2019

Genome mapping and assays unveil IL1RAP's epigenetic control.

How can we unravel IL1RAP's varied distribution across cell types and tissues, clarifying its functional versatility? 11/05/2017

Innovative methods clarify IL1RAP's distribution diversity, revealing its functional adaptability.

How do advanced imaging and genetic knockout models shed light on IL1RAP's role in immune cell dynamics and functions? 05/01/2017

Advanced imaging and genetic models illuminate IL1RAP's immune role.

What insights do computational simulations and in vitro experiments provide into IL1RAP's interaction kinetics and stability? 11/04/2016

Simulations and experiments reveal IL1RAP's interaction details.

Do engineered cellular models clarify IL1RAP's mechanisms in inflammasome activation and cytokine release? 08/20/2016

Engineered cell models shed light on IL1RAP's role in inflammation.

Can structural biology techniques elucidate IL1RAP's conformational changes and ligand interactions in inflammation? 07/25/2016

Structural techniques provide insights into IL1RAP's ligand interactions.

What strategies unveil the influence of post-translational modifications on IL1RAP's localization and signaling pathways? 07/19/2016

Strategies uncover post-translational effects on IL1RAP's signaling.

How do organ-on-chip technologies mimic tissue microenvironments to explore IL1RAP's impact on signaling pathways? 07/14/2016

Organ-on-chip tech explores IL1RAP's impact on pathways.

What innovative methods decode IL1RAP isoforms in different cells, revealing their impact on cellular responses? 06/07/2016

Novel techniques decode IL1RAP isoforms, exposing their influence on cell responses.

Customer Reviews (3)

Write a review
Reviews
05/25/2021

    High solubility.

    07/22/2019

      Good for intracellular staining.

      05/13/2018

        Effective in apoptosis assays.

        Ask a Question for All IL1RAP Products

        Required fields are marked with *

        My Review for All IL1RAP Products

        Required fields are marked with *

        logo

        FOLLOW US

        Terms and Conditions        Privacy Policy

        Copyright © 2024 Creative BioMart. All Rights Reserved.

        Contact Us

        • /
        • Service lnquiry:

        Stay Updated on the Latest Bioscience Trends