Recombinant Mouse Inava Protein, Myc/DDK-tagged

• Cat.No.: Inava-3534M
• Product Overview: Purified recombinant protein of mouse full-length innate immunity activator (Inava), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Expressed in peripheral macrophages and intestinal myeloid-derived cells, is required for optimal PRR (pattern recognition receptor)-induced signaling, cytokine secretion, and bacterial clearance. Upon stimulation of a broad range of PRRs (pattern recognition receptor) such as NOD2 or TLR2, TLR3, TLR4, TLR5, TLR7 and TLR9, associates with YWHAQ/14-3-3T, which in turn leads to the recruitment and activation of MAP kinases and NF-kappa-B signaling complexes that amplifies PRR-induced downstream signals and cytokine secretion. In the intestine, regulates adherens junction stability by regulating the degradation of CYTH1 and CYTH2, probably acting as substrate cofactor for SCF E3 ubiquitin-protein ligase complexes. Stabilizes adherens junctions by limiting CYTH1-dependent ARF6 activation.
• Molecular Mass: 72.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Inava innate immunity activator [ Mus musculus (house mouse) ]
• Official Symbol: Inava
• Synonyms: Inava; innate immunity activator; D1Mgi54; AI586180; 1700034M08Rik; 4933426C09Rik; 5730559C18Rik; innate immunity activator protein; uncharacterized protein C1orf106 homolog
• Gene ID: 67313
• mRNA Refseq: NM_028872
• Protein Refseq: NP_083148
• UniProt ID: Q7TN12