Recombinant Mouse KLK14 Protein (24-250 aa), His-tagged

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Recombinant Mouse KLK14 Protein (24-250 aa), His-tagged

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Cat.No. : KLK14-2159M
Product Overview : Recombinant Mouse KLK14 Protein (24-250 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Tags & Cell Markers. Protein Description: Full Length of Mature Protein.
Description : Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese.
Source : Yeast
Species : Mouse
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 26.5 kDa
Protein length : 24-250 aa
AA Sequence : IIGGYRCVRN SQPWQVALQA GPGHRFLCGG VLLSDQWVIT AAHCARPILH VALGKHNIRR WEATQQVVRV ARQVPHPQYQ PQAHDNDLML LKLQKKVRLG RAVKTISVAS SCASPGTPCR VSGWGTIASP IARYPTALQC VNVNIMSEQA CHRAYPGIIT SGMVCAGVPE GGKDSCQGDS GGPLVCGGQL QGLVSWGMER CAMPGYPGVY ANLCNYHSWI QRTMQSN
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : Klk14 kallikrein related-peptidase 14 [ Mus musculus ]
Official Symbol : KLK14
Synonyms : KLK14; kallikrein-14; mGK14; kallikrein 14; GK14; MGC157618;
Gene ID : 317653
mRNA Refseq : NM_174866
Protein Refseq : NP_777355
UniProt ID : Q8CGR5
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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