Recombinant Mouse KLK14 Protein (24-250 aa), His-tagged

• Cat.No.: KLK14-2159M
• Product Overview: Recombinant Mouse KLK14 Protein (24-250 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Research Area: Tags & Cell Markers. Protein Description: Full Length of Mature Protein.

Specification

• Description: Serine-type endopeptidase with a dual trypsin-like and chymotrypsin-like substrate specificity. May activate/inactivate the proteinase-activated receptors F2R, F2RL1 and F2RL3 and other kallikreins including KLK1, KLK3, KLK5 and KLK11. May function in seminal clot liquefaction through direct cleavage of the semenogelin SEMG1 and SEMG2 and activation of KLK3. May function through desmoglein DSG1 cleavage in epidermal desquamation a process by which the most superficial corneocytes are shed from the skin surface. May be involved in several aspects of tumor progression including growth, invasion and angiogenesis Inhibited by SERPINA1, SERPINC1, SERPINE1, SERPINF2, aprotinin, soybean, trypsin inhibitor and leupeptin. Inhibited by serine protease inhibitor SPINK5. Has an autoproteolytic activity which may have a regulatory effect. Activated by citrate and inhibited by zinc and to a lower extent by manganese.
• Source: Yeast
• Species: Mouse
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 26.5 kDa
• Protein length: 24-250 aa
• AA Sequence: IIGGYRCVRNSQPWQVALQAGPGHR FLCGGVLLSDQWVITAAHCARPILH VALGKHNIRRWEATQQVVRVARQVP HPQYQPQAHDNDLMLLKLQKKVRLG RAVKTISVASSCASPGTPCRVSGWG TIASPIARYPTALQCVNVNIMSEQA CHRAYPGIITSGMVCAGVPEGGKDS CQGDSGGPLVCGGQLQGLVSWGMER CAMPGYPGVYANLCNYHSWIQRTMQ SN
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: Klk14 kallikrein related-peptidase 14 [ Mus musculus ]
• Official Symbol: KLK14
• Synonyms: KLK14; kallikrein-14; mGK14; kallikrein 14; GK14; MGC157618
• Gene ID: 317653
• mRNA Refseq: NM_174866
• Protein Refseq: NP_777355
• UniProt ID: Q8CGR5