Recombinant Mouse Kpna6 Protein, MYC/DDK-tagged Kpna6-1281M

Recombinant Mouse Kpna6 Protein, MYC/DDK-tagged

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Recombinant Mouse Kpna6 Protein, MYC/DDK-tagged

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Cat.No. : Kpna6-1281M
Product Overview : Purified recombinant protein of full-length mouse karyopherin (importin) alpha 6 (Kpna6), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.
Description : Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 60 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Kpna6 karyopherin (importin) alpha 6 [ Mus musculus (house mouse) ]
Official Symbol : Kpna6
Synonyms : Kpna6; karyopherin (importin) alpha 6; IPOA7; Kpna5; NPI-2; importin subunit alpha-7; importin alpha 7; importin alpha-S2; karyopherin (importin) alpha 5; karyopherin subunit alpha-6
Gene ID : 16650
mRNA Refseq : NM_008468
Protein Refseq : NP_032494
UniProt ID : O35345

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