Recombinant Mouse LINGO1 Protein (37-555 aa), His-tagged

• Cat.No.: LINGO1-2333M
• Product Overview: Recombinant Mouse LINGO1 Protein (37-555 aa) is produced by Yeast expression system. This protein is fused with a 6xHis tag at the N-terminal. Protein Description: Partial.

Specification

• Description: Functional component of the Nogo receptor signaling complex (RTN4R/NGFR) in RhoA activation responsible for some inhibition of axonal regeneration by myelin-associated factors. Is also an important negative regulator of oligodentrocyte differentiation and axonal myelination . Acts in conjunction with RTN4 and RTN4R in regulating neuronal precursor cell motility during cortical development.1 Publication.
• Source: Yeast
• Species: Mouse
• Tag: His
• Form: Tris-based buffer,50% glycerol
• Molecular Mass: 60.9 kDa
• Protein length: 37-555 aa
• AA Sequence: PPRCECSAQDRAVLCHRKRFVAVPE GIPTETRLLDLGKNRIKTLNQDEFA SFPHLEELELNENIVSAVEPGAFNN LFNLRTLGLRSNRLKLIPLGVFTGL SNLTKLDISENKIVILLDYMFQDLY NLKSLEVGDNDLVYISHRAFSGLNS LEQLTLEKCNLTSIPTEALSHLHGL IVLRLRHLNINAIRDYSFKRLYRLK VLEISHWPYLDTMTPNCLYGLNLTS LSITHCNLTAVPYLAVRHLVYLRFL NLSYNPIGTIEGSMLHELLRLQEIQ LVGGQLAVVEPYAFRGLNYLRVLNV SGNQLTTLEESAFHSVGNLETLILD SNPLACDCRLLWVFRRRWRLNFNRQ QPTCATPEFVQGKEFKDFPDVLLPN YFTCRRAHIRDRKAQQVFVDEGHTV QFVCRADGDPPPAILWLSPRKHLVS AKSNGRLTVFPDGTLEVRYAQVQDN GTYLCIAANAGGNDSMPAHLHVRSY SPDWPHQPNKTFAFISNQPGEGEAN STRATVPFPFDIKTLIIAT
• Purity: > 90% as determined by SDS-PAGE.
• Notes: Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
• Storage: The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
• Concentration: A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.

Gene Information

• Gene Name: Lingo1 leucine rich repeat and Ig domain containing 1 [ Mus musculus ]
• Official Symbol: LINGO1
• Synonyms: LINGO1; LERN1; Lrrn6a; UNQ201; LINGO-1; AV148400; 4930471K13Rik
• Gene ID: 235402
• mRNA Refseq: NM_181074
• Protein Refseq: NP_851419
• UniProt ID: Q9D1T0