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Recombinant Mouse Lmna Protein, MYC/DDK-tagged

Cat.No. : Lmna-1324M
Product Overview : Purified recombinant protein of full-length mouse lamin A (Lmna), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.
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Description : This gene encodes a protein that is a member of the lamin family. Nuclear lamins, intermediate filament-like proteins, are the major components of the nuclear lamina, a protein meshwork associated with the inner nuclear membrane. This meshwork is thought to maintain the integrity of the nuclear envelope, participate in chromatin organization, and regulate gene transcription. Vertebrate lamins consist of two types, A and B. This protein is an A-type and is proposed to be developmentally regulated. In mouse deficiency of this gene is associated with muscular dystrophy. Mouse lines with different mutations in this gene serve as pathophysiological models for several human laminopathies. In humans, mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 74.2 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Lmna lamin A [ Mus musculus (house mouse) ]
Official Symbol : Lmna
Synonyms : Lmna; lamin A; Dhe; prelamin-A/C; lamin C; lamin-A/C
Gene ID : 16905
mRNA Refseq : NM_001002011
Protein Refseq : NP_001002011
UniProt ID : P48678

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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Q&As (7)

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How does LMNA interact with other structural proteins? 02/28/2021

LMNA interacts with various structural proteins, playing a key role in the nuclear architecture.

How do genetic variations in LMNA affect cellular mechanics? 10/27/2018

Genetic alterations in LMNA can impair the structural stability of the nucleus, affecting overall cell function.

What potential therapeutic applications arise from targeting LMNA-related disorders? 08/26/2018

Targeting LMNA mutations could offer therapeutic strategies for conditions like progeria and cardiac diseases.

What is the primary role of LMNA in cellular structure? 05/07/2018

LMNA, encoding lamin proteins, is vital for maintaining the structural integrity of the nucleus in cells.

How does LMNA contribute to nuclear envelope stability? 12/29/2017

It contributes to nuclear envelope stability, ensuring proper nuclear shape and mechanical support.

What role does LMNA play in genetic disorders like progeria? 08/01/2017

LMNA mutations are associated with progeria, leading to premature aging and related phenotypes.

What is the impact of altered LMNA activity on cardiovascular health? 07/17/2017

Altered LMNA activity is linked to cardiovascular diseases, influencing heart muscle function and structure.

Customer Reviews (3)

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Reviews
07/26/2022

    Efficient and precise. Enhances research quality.

    05/10/2022

      Crucial for research integrity. Trusted for insights.

      01/29/2018

        Dependable partner. Supports our research endeavors.

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