Recombinant Mouse Lmna Protein, MYC/DDK-tagged Lmna-1324M

Recombinant Mouse Lmna Protein, MYC/DDK-tagged

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Recombinant Mouse Lmna Protein, MYC/DDK-tagged

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Cat.No. : Lmna-1324M
Product Overview : Purified recombinant protein of full-length mouse lamin A (Lmna), with C-terminal MYC/DDK tag, was expressed in HEK293T cells.
Description : This gene encodes a protein that is a member of the lamin family. Nuclear lamins, intermediate filament-like proteins, are the major components of the nuclear lamina, a protein meshwork associated with the inner nuclear membrane. This meshwork is thought to maintain the integrity of the nuclear envelope, participate in chromatin organization, and regulate gene transcription. Vertebrate lamins consist of two types, A and B. This protein is an A-type and is proposed to be developmentally regulated. In mouse deficiency of this gene is associated with muscular dystrophy. Mouse lines with different mutations in this gene serve as pathophysiological models for several human laminopathies. In humans, mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. Alternative splicing results in multiple transcript variants that encode different protein isoforms.
Source : HEK293T
Species : Mouse
Tag : MYC/DDK
Molecular Mass : 74.2 kDa
Purity : >80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 µg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Lmna lamin A [ Mus musculus (house mouse) ]
Official Symbol : Lmna
Synonyms : Lmna; lamin A; Dhe; prelamin-A/C; lamin C; lamin-A/C
Gene ID : 16905
mRNA Refseq : NM_001002011
Protein Refseq : NP_001002011
UniProt ID : P48678

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