Recombinant Mouse Mbnl3 Protein, Myc/DDK-tagged

• Cat.No.: Mbnl3-3983M
• Product Overview: Purified recombinant protein of mouse full-length muscleblind like splicing factor 3 (Mbnl3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Could inhibit terminal muscle differentiation, acting at approximately the time of myogenin induction.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 37.6 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mbnl3 muscleblind like splicing factor 3 [ Mus musculus (house mouse) ]
• Official Symbol: Mbnl3
• Synonyms: MBNL3; muscleblind-like 3 (Drosophila); muscleblind-like protein 3; cys3His CCG1-required protein; muscleblind-like X-linked protein; CHCR; MBLX; MBXL; MBLX39; AI661274; A530038J18Rik; E430034C16Rik
• Gene ID: 171170
• mRNA Refseq: NM_134163
• Protein Refseq: NP_598924
• UniProt ID: Q8R003