Recombinant Mouse Mtmr9 Protein, Myc/DDK-tagged

• Cat.No.: Mtmr9-4220M
• Product Overview: Purified recombinant protein of mouse full-length myotubularin related protein 9 (Mtmr9), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Acts as an adapter for myotubularin-related phosphatases. Increases lipid phosphatase MTMR6 catalytic activity, specifically towards phosphatidylinositol 3,5-bisphosphate, and MTMR6 binding affinity for phosphorylated phosphatidylinositols. Positively regulates lipid phosphatase MTMR7 catalytic activity. The formation of the MTMR6-MTMR9 complex, stabilizes both MTMR6 and MTMR9 protein levels. Plays a role in the late stages of macropinocytosis possibly by regulating MTMR6-mediated dephosphorylation of phosphatidylinositol 3-phosphate in membrane ruffles. Negatively regulates DNA damage-induced apoptosis, in part via its association with MTMR6. Does not bind mono-, di- and tri-phosphorylated phosphatidylinositols, phosphatidic acid and phosphatidylserine.
• Molecular Mass: 63.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Mtmr9 myotubularin related protein 9 [ Mus musculus (house mouse) ]
• Official Symbol: Mtmr9
• Synonyms: MTMR9; myotubularin related protein 9; myotubularin-related protein 9; MTMR8; mMTMH3; AA516943; AF073881; LIP-STYX; 9430075G12Rik; MGC54783
• Gene ID: 210376
• mRNA Refseq: NM_177594
• Protein Refseq: NP_808262
• UniProt ID: Q9Z2D0