Recombinant Mouse Pgrmc2 Protein, Myc/DDK-tagged

• Cat.No.: PGRMC2-12701M
• Product Overview: Purified recombinant protein of Mouse progesterone receptor membrane component 2 (Pgrmc2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. May serve as a universal non-classical progesterone receptor in the uterus. Intracellular heme chaperone required for delivery of labile, or signaling heme, to the nucleus. Plays a role in adipocyte function and systemic glucose homeostasis. In brown fat, which has a high demand for heme, delivery of labile heme in the nucleus regulates the activity of heme-responsive transcriptional repressors such as NR1D1 and BACH1.
• Source: HEK293T
• Species: Mouse
• Tag: C-Myc/DDK
• Molecular Mass: 23.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Pgrmc2 progesterone receptor membrane component 2 [ Mus musculus (house mouse) ]
• Official Symbol: Pgrmc2
• Synonyms: Pgrmc2; progesterone receptor membrane component 2; DG6; PMBP; 4631434O19Rik; 5730409G06Rik; membrane-associated progesterone receptor component 2; progesterone membrane binding protein
• Gene ID: 70804
• mRNA Refseq: NM_027558
• Protein Refseq: NP_081834
• UniProt ID: Q80UU9