Recombinant Mouse Ppargc1a Protein, His-tagged

• Cat.No.: Ppargc1a-1962M
• Product Overview: Recombinant Mouse Ppargc1a Protein (Glu349-Arg797) with N-His tag was expressed in E. coli.

Specification

• Description: This gene encodes a transcriptional coactivator that induces and coordinates gene expression regulating mitochondrial biogenesis, respiration, hepatic gluconeogenesis, thermogenic program in brown fat and muscle fiber-type switching. Mice lacking the encoded protein exhibit reduced thermogenic capacity, hyperactivity and resistance to diet-induced obesity. Mice lacking the encoded protein specifically in the heart exhibit peripartum cardiomyopathy. Alternative splicing results in multiple transcript variants.
• Source: E. coli
• Species: Mouse
• Tag: N-His
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 56.4 kDa
  Accurate Molecular Mass: 56 kDa
• Protein length: Glu349-Arg797
• Purity: > 80%
• Applications: Positive Control; Immunogen; SDS-PAGE; WB.
• Stability: The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37 centigrade for 48h, and no obvious degradation and precipitation were observed. The loss rate is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8 centigrade for one month. Aliquot and store at -80 centigrade for 12 months.
• Storage Buffer: PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
• Reconstitution: Reconstitute in 20mM Tris, 150mM NaCl (pH8.0) to a concentration of 0.1-1.0 mg/mL. Do not vortex.

Gene Information

• Gene Name: Ppargc1a peroxisome proliferative activated receptor, gamma, coactivator 1 alpha [ Mus musculus (house mouse) ]
• Official Symbol: Ppargc1a
• Synonyms: PPARGC1A; peroxisome proliferative activated receptor, gamma, coactivator 1 alpha; peroxisome proliferator-activated receptor gamma coactivator 1-alpha; PGC-1-alpha; Pgc-1alphaa; PPARGC-1-alpha; PPAR Gamma Coactivator-1; PPAR-gamma coactivator 1-alpha; PPAR gamma coactivator variant form; Pgc1; PGC-1; Pgco1; PGC-1v; Gm11133; Ppargc1; Pgc-1alpha; A830037N07Rik; ENSMUSG00000079510
• Gene ID: 19017
• mRNA Refseq: NM_008904
• Protein Refseq: NP_032930
• UniProt ID: O70343