Recombinant Mouse Rab1a Protein, Myc/DDK-tagged

• Cat.No.: Rab1a-5294M
• Product Overview: Purified recombinant protein of mouse full-length RAB1A, member RAS oncogene family (Rab1a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB1A regulates vesicular protein transport from the endoplasmic reticulum (ER) to the Golgi compartment and on to the cell surface, and plays a role in IL-8 and growth hormone secretion. Regulates the level of CASR present at the cell membrane. Plays a role in cell adhesion and cell migration, via its role in protein trafficking. Plays a role in autophagosome assembly and cellular defense reactions against pathogenic bacteria. Plays a role in microtubule-dependent protein transport by early endosomes and in anterograde melanosome transport.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 22.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rab1a RAB1A, member RAS oncogene family [ Mus musculus (house mouse) ]
• Official Symbol: Rab1a
• Synonyms: Rab1a; RAB1A, member RAS oncogene family; Ra; Gtb; Rab; Ypt; Gtbp; Rab1; Ypt1; Rab-1; mKIAA3012; ras-related protein Rab-1A; RAB1, member RAS oncogene family; YPT1-related protein; ras-related YPT1 protein
• Gene ID: 19324
• mRNA Refseq: NM_008996
• Protein Refseq: NP_033022
• UniProt ID: P62821