Recombinant Mouse Ralb Protein, Myc/DDK-tagged

• Cat.No.: Ralb-5358M
• Product Overview: Purified recombinant protein of mouse full-length v-ral simian leukemia viral oncogene B (Ralb), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. Required both to stabilize the assembly of the exocyst complex and to localize functional exocyst complexes to the leading edge of migrating cells. Required for suppression of apoptosis. In late stages of cytokinesis, upon completion of the bridge formation between dividing cells, mediates exocyst recruitment to the midbody to drive abscission.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 23.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ralb v-ral simian leukemia viral oncogene B [ Mus musculus (house mouse) ]
• Official Symbol: Ralb
• Synonyms: RALB; v-ral simian leukemia viral oncogene homolog B (ras related); ras-related protein Ral-B; 5730472O18Rik
• Gene ID: 64143
• mRNA Refseq: NM_022327
• Protein Refseq: NP_071722
• UniProt ID: Q9JIW9