Recombinant Mouse Ran Protein, Myc/DDK-tagged

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Recombinant Mouse Ran Protein, Myc/DDK-tagged

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Cat.No. : Ran-5364M
Product Overview : Purified recombinant protein of mouse full-length RAN, member RAS oncogene family (Ran), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : GTPase involved in nucleocytoplasmic transport, participating both to the import and the export from the nucleus of proteins and RNAs. Switches between a cytoplasmic GDP- and a nuclear GTP-bound state by nucleotide exchange and GTP hydrolysis. Nuclear import receptors such as importin beta bind their substrates only in the absence of GTP-bound RAN and release them upon direct interaction with GTP-bound RAN, while export receptors behave in the opposite way. Thereby, RAN controls cargo loading and release by transport receptors in the proper compartment and ensures the directionality of the transport. Interaction with RANBP1 induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. RAN (GTP-bound form) triggers microtubule assembly at mitotic chromosomes and is required for normal mitotic spindle assembly and chromosome segregation. Required for normal progress through mitosis. The complex with BIRC5/survivin plays a role in mitotic spindle formation by serving as a physical scaffold to help deliver the RAN effector molecule TPX2 to microtubules. Acts as a negative regulator of the kinase activity of VRK1 and VRK2. Enhances AR-mediated transactivation.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 24.9 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Ran RAN, member RAS oncogene family [ Mus musculus (house mouse) ]
Official Symbol : Ran
Synonyms : RAN; RAN, member RAS oncogene family; GTP-binding nuclear protein Ran; GTPase Ran; ras-like protein TC4; ras-related nuclear protein
Gene ID : 19384
mRNA Refseq : NM_009391
Protein Refseq : NP_033417
UniProt ID : P62827

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