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Recombinant Mouse Ranbp3 Protein, Myc/DDK-tagged

Cat.No. : Ranbp3-5367M
Product Overview : Purified recombinant protein of mouse full-length RAN binding protein 3 (Ranbp3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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Description : Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 52.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Ranbp3 RAN binding protein 3 [ Mus musculus (house mouse) ]
Official Symbol : Ranbp3
Synonyms : RANBP3; RAN binding protein 3; ran-binding protein 3; AA408221; 2610024N24Rik
Gene ID : 71810
mRNA Refseq : NM_027933
Protein Refseq : NP_082209
UniProt ID : Q9CT10

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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