Recombinant Mouse Ranbp3 Protein, Myc/DDK-tagged

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Recombinant Mouse Ranbp3 Protein, Myc/DDK-tagged

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Cat.No. : Ranbp3-5367M
Product Overview : Purified recombinant protein of mouse full-length RAN binding protein 3 (Ranbp3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
Description : Acts as a cofactor for XPO1/CRM1-mediated nuclear export, perhaps as export complex scaffolding protein. Bound to XPO1/CRM1, stabilizes the XPO1/CRM1-cargo interaction. In the absence of Ran-bound GTP prevents binding of XPO1/CRM1 to the nuclear pore complex. Binds to CHC1/RCC1 and increases the guanine nucleotide exchange activity of CHC1/RCC1. Recruits XPO1/CRM1 to CHC1/RCC1 in a Ran-dependent manner. Negative regulator of TGF-beta signaling through interaction with the R-SMAD proteins, SMAD2 and SMAD3, and mediating their nuclear export.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 52.6 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Ranbp3 RAN binding protein 3 [ Mus musculus (house mouse) ]
Official Symbol : Ranbp3
Synonyms : RANBP3; RAN binding protein 3; ran-binding protein 3; AA408221; 2610024N24Rik
Gene ID : 71810
mRNA Refseq : NM_027933
Protein Refseq : NP_082209
UniProt ID : Q9CT10

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