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Recombinant Mouse Rfx3 Protein, Myc/DDK-tagged

Cat.No. : Rfx3-5481M
Product Overview : Purified recombinant protein of mouse full-length regulatory factor X, 3 (influences HLA class II expression) (Rfx3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.
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  • Gene Information
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Description : Transcription factor required for ciliogenesis and islet cell differentiation during endocrine pancreas development. Essential for the differentiation of nodal monocilia and left-right asymmetry specification during embryogenesis. Required for the biogenesis of motile cilia by governing growth and beating efficiency of motile cells. Also required for ciliated ependymal cell differentiation. Together with RFX6, participates in the differentiation of 4 of the 5 islet cell types during endocrine pancreas development, with the exception of pancreatic PP (polypeptide-producing) cells. Regulates transcription by forming a heterodimer with another RFX protein and binding to the X-box in the promoter of target genes. Regulates the expression of genes involved in ciliary assembly (DYNC2LI1, FOXJ1 and BBS4) and genes involved in ciliary motility (DNAH11, DNAH9 and DNAH5). Represses transcription of MAP1A in non-neuronal cells but not in neuronal cells.
Source : HEK293T
Species : Mouse
Tag : Myc/DDK
Molecular Mass : 83.5 kDa
Purity : > 80% as determined by SDS-PAGE and Coomassie blue staining
Stability : Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
Storage : Store at -80 centigrade after receiving vials.
Concentration : >50 μg/mL as determined by microplate BCA method
Storage Buffer : 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.
Gene Name : Rfx3 regulatory factor X, 3 (influences HLA class II expression) [ Mus musculus (house mouse) ]
Official Symbol : Rfx3
Synonyms : RFX3; regulatory factor X, 3 (influences HLA class II expression); transcription factor RFX3; regulatory factor X 3; MRFX3; C230093O12Rik
Gene ID : 19726
mRNA Refseq : NM_011265
Protein Refseq : NP_035395
UniProt ID : P48381

For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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