Recombinant Mouse Rmnd5a Protein, Myc/DDK-tagged

• Cat.No.: Rmnd5a-5531M
• Product Overview: Purified recombinant protein of mouse full-length required for meiotic nuclear division 5 homolog A (Rmnd5a), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex. Catalytic activity of the complex is required for normal cell proliferation. The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 44 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Rmnd5a required for meiotic nuclear division 5 homolog A [ Mus musculus (house mouse) ]
• Official Symbol: Rmnd5a
• Synonyms: RMND5A; required for meiotic nuclear division 5 homolog A (S. cerevisiae); protein RMD5 homolog A; AJ237586; AW125795; MTA.D02.090; 1110007A06Rik; MGC59617
• Gene ID: 68477
• mRNA Refseq: NM_024288
• Protein Refseq: NP_077250
• UniProt ID: Q80YQ8