Recombinant Mouse SERPINA5 Protein (25-405 aa), His-tagged

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Recombinant Mouse SERPINA5 Protein (25-405 aa), His-tagged

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Cat.No. : SERPINA5-2816M
Product Overview : Recombinant Mouse SERPINA5 Protein (25-405 aa) is produced by Baculovirus expression system. This protein is fused with a 10xHis tag at the N-terminal. Research Area: Cancer. Protein Description: Full Length of Mature Protein.
Description : Heparin-dependent serine protease inhibitor acting in body fluids and secretions. Inactivates serine proteases by binding irreversibly to their serine activation site. Involved in the regulation of intravascular and extravascular proteolytic activities. Plays hemostatic roles in the blood plasma. Acts as a procoagulant and proinflammatory factor by inhibiting the anticoagulant activated protein C factor as well as the generation of activated protein C factor by the thrombin/thrombomodulin complex. Acts as an anticoagulant factor by inhibiting blood coagulation factors like prothrombin, factor XI, factor Xa, plasma kallikrein and fibrinolytic enzymes such as tissue- and urinary-type plasminogen activators. In seminal plasma, inactivates several serine proteases implicated in the reproductive system. Inhibits the serpin acrosin; indirectly protects component of the male genital tract from being degraded by excessive released acrosin. Inhibits tissue-and urinary-type plasminogen activator, prostate-specific antigen and kallikrein activities; has a control on the sperm motility and fertilization. Inhibits the activated protein C-catalyzed degradation of SEMG1 and SEMG2; regulates the degradation of semenogelin during the process of transfer of spermatozoa from the male reproductive tract into the female tract. In urine, inhibits urinary-type plasminogen activator and kallikrein activities. Inactivates membrane-anchored serine proteases activities such as MPRSS7 and TMPRSS11E. Inhibits urinary-type plasminogen activator-dependent tumor cell invasion and metastasis. May also play a non-inhibitory role in seminal plasma and urine as a hydrophobic hormone carrier by its binding to retinoic acid.
Source : Baculovirus
Species : Mouse
Tag : His
Form : Tris-based buffer,50% glycerol
Molecular Mass : 45.3 kDa
Protein length : 25-405 aa
AA Sequence : SKKKKAKESS VGAVGPPSSK DFAFRLYRAL VSESPGQNVF FSPLSVSMSL GMLSLGAGLK TKTQILDGLG LSLQQGQEDK LHKGFQQLLQ RFRQPSDGLQ LSLGSALFKD PAVHIRDDFL SAMKTLYMSD TFSTNFGNPE IAKKQINNYV AKQTKGKIVD FIKDLDSTHV MIVVNYIFFK AKWQTAFSET NTHKMDFHVT PKRTTQVPMM NREDGYSYYL DQNISCTVVG IPYQGNAIAL FILPSEGKMK QVEDGLDERT LRNWLKMFTK RRLDLYLPKF SIEATYKLEN VLPKLGIQDV FTTHADLSGI TDHTNIKLSE MVHKSMMEVE ESGTTAAAIT GAIFTFRSAR PSSLKIEFTR PFLLTLMEDS HILFVGKVTR P
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA will be sent along with the products. Please refer to it for detailed information.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : Serpina5 serine (or cysteine) peptidase inhibitor, clade A, member 5 [ Mus musculus ]
Official Symbol : SERPINA5
Synonyms : SERPINA5; PAI3; serpin A5; antitrypsin; protein C inhibitor; alpha-1 antiproteinase; Pci; PAI-3; 4933415L04;
Gene ID : 268591
mRNA Refseq : NM_172953
Protein Refseq : NP_766541
UniProt ID : P70458

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