Recombinant Mouse Sike1 Protein, Myc/DDK-tagged

• Cat.No.: Sike1-5879M
• Product Overview: Purified recombinant protein of mouse full-length suppressor of IKBKE 1 (Sike1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Physiological suppressor of IKK-epsilon and TBK1 that plays an inhibitory role in virus- and TLR3-triggered IRF3. Inhibits TLR3-mediated activation of interferon-stimulated response elements (ISRE) and the IFN-beta promoter. May act by disrupting the interactions of IKBKE or TBK1 with TICAM1/TRIF, IRF3 and DDX58/RIG-I. Does not inhibit NF-kappa-B activation pathways.
• Molecular Mass: 23.5 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Sike1 suppressor of IKBKE 1 [ Mus musculus (house mouse) ]
• Official Symbol: Sike1
• Synonyms: Sike; Sikeb; AI450236; AI839862; 2810005O12Rik; 5730470L24Rik
• Gene ID: 66641
• mRNA Refseq: NM_025679
• Protein Refseq: NP_079955
• UniProt ID: Q9CPR7