Recombinant Mouse Stam Protein, Myc/DDK-tagged

• Cat.No.: Stam-6157M
• Product Overview: Purified recombinant protein of mouse full-length signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 (Stam), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 59.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Stam signal transducing adaptor molecule (SH3 domain and ITAM motif) 1 [ Mus musculus (house mouse) ]
• Official Symbol: Stam
• Synonyms: STAM; signal transducing adaptor molecule (SH3 domain and ITAM motif) 1; signal transducing adapter molecule 1; STAM-1; STAM1
• Gene ID: 20844
• mRNA Refseq: NM_011484
• Protein Refseq: NP_035614
• UniProt ID: P70297