Recombinant Mouse Taok3 Protein, Myc/DDK-tagged

• Cat.No.: Taok3-6291M
• Product Overview: Purified recombinant protein of mouse full-length TAO kinase 3 (Taok3), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Serine/threonine-protein kinase that acts as a regulator of the p38/MAPK14 stress-activated MAPK cascade and of the MAPK8/JNK cascade. Acts as an activator of the p38/MAPK14 stress-activated MAPK cascade. In response to DNA damage, involved in the G2/M transition DNA damage checkpoint by activating the p38/MAPK14 stress-activated MAPK cascade, probably by mediating phosphorylation of upstream MAP2K3 and MAP2K6 kinases. Inhibits basal activity of MAPK8/JNK cascade and diminishes its activation in response epidermal growth factor (EGF).
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 105.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Taok3 TAO kinase 3 [ Mus musculus (house mouse) ]
• Official Symbol: Taok3
• Synonyms: TAOK3; TAO kinase 3; serine/threonine-protein kinase TAO3; thousand and one amino acid protein 3; A130052D22; 2900006A08Rik; A430105I05Rik
• Gene ID: 330177
• mRNA Refseq: NM_001081308
• Protein Refseq: NP_001074777
• UniProt ID: Q8BYC6