Recombinant Mouse Tctn1 Protein, Myc/DDK-tagged

• Cat.No.: Tctn1-6346M
• Product Overview: Purified recombinant protein of mouse full-length tectonic family member 1 (Tctn1), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Regulator of Hedgehog (Hh), required for both activation and inhibition of the Hh pathway in the patterning of the neural tube. During neural tube development, it is required for formation of the most ventral cell types and for full Hh pathway activation. Functions in Hh signal transduction to fully activate the pathway in the presence of high Hh levels and to repress the pathway in the absence of Hh signals. Modulates Hh signal transduction downstream of SMO and RAB23.
• Molecular Mass: 63.9 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tctn1 tectonic family member 1 [ Mus musculus (house mouse) ]
• Official Symbol: Tctn1
• Synonyms: Tctn1; tectonic family member 1; Tect1; 4930565B19R; 4930565B19Rik; G730031O11Rik; tectonic-1
• Gene ID: 654470
• mRNA Refseq: NM_001039153
• Protein Refseq: NP_001034242
• UniProt ID: Q8BZ64