Recombinant Mouse Tm4sf20 Protein, Myc/DDK-tagged

• Cat.No.: Tm4sf20-6457M
• Product Overview: Purified recombinant protein of mouse full-length transmembrane 4 L six family member 20 (Tm4sf20), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Polytopic transmembrane protein. Inhibits regulated intramembrane proteolysis (RIP) of CREB3L1, inhibiting its activation and the induction of collagen synthesis. In response to ceramide, which alters TM4SF20 membrane topology, stimulates RIP activation of CREB3L1. Ceramide reverses the direction through which transmembrane helices are translocated into the endoplasmic reticulum membrane during translation of TM4SF20, this mechanism is called 'regulated alternative translocation' (RAT) and regulates the function of the transmembrane protein.
• Molecular Mass: 25.2 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tm4sf20 transmembrane 4 L six family member 20 [ Mus musculus (house mouse) ]
• Official Symbol: Tm4sf20
• Synonyms: TM4SF20; transmembrane 4 L six family member 20; transmembrane 4 L6 family member 20; 1810018L02Rik; MGC143474
• Gene ID: 66261
• mRNA Refseq: NM_025453
• Protein Refseq: NP_079729
• UniProt ID: Q9CQY8