Recombinant Mouse Tmem59 Protein, Myc/DDK-tagged

• Cat.No.: Tmem59-6512M
• Product Overview: Purified recombinant protein of mouse full-length transmembrane protein 59 (Tmem59), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Acts as a regulator of autophagy in response to S.aureus infection by promoting activation of LC3 (MAP1LC3A, MAP1LC3B or MAP1LC3C). Acts by interacting with ATG16L1, leading to promote a functional complex between LC3 and ATG16L1 and promoting LC3 lipidation and subsequent activation of autophagy. Modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP. Inhibits APP transport to the cell surface and further shedding.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 36.3 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Tmem59 transmembrane protein 59 [ Mus musculus (house mouse) ]
• Official Symbol: Tmem59
• Synonyms: TMEM59; transmembrane protein 59; thymic dendritic cell-derived factor 1; ORF18; MTDCF1; AI256529; D4Ertd20e; 1110001M20Rik; 3110046P06Rik
• Gene ID: 56374
• mRNA Refseq: NM_029565
• Protein Refseq: NP_083841
• UniProt ID: Q9QY73