|Product Overview:||Recombinant Mouse Tnfsf18(Thr 47 - Ser 173) fused with human IgG1 Fc tag at the N-terminus was expressed in HEK293.|
|Description:||Tumor necrosis factor ligand superfamily member 18 (TNFSF18) is also known as Glucocorticoid - induced TNF-related ligand (GITRL or GITR Ligand), Activation - inducible TNF - related ligand (AITRL), which belongs to the tumor necrosis factor family. TNFSF18 is expressed at high levels in the small intestine, ovary, testis, kidney and endothelial cells. TNFSF18 / GITRL is up-regulated after stimulation by bacterial lipopolysaccharides (LPS). TNFSF18 Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. TNFSF18 / GITR Ligand is important for interactions between activated T-lymphocytes and endothelial cells. TNFSF18 also mediates activation of NF-kappa-B.|
|Form:||Lyophilized from 0.22 μm filtered solution in 50 mM Tris,100 mM Glycine,pH7.5. Normally trehalose is added as protectant before lyophilization.|
|Molecular Mass:||The protein has a calculated MW of 41.4 kDa. As a result of glycosylation, The protein migrates as 45 kDa under reducing (R) condition and 80-100 kDa under non-reducing (NR) condition on SDS-PAGE gel.|
|Protein length:||Thr 47 - Ser 173|
|Endotoxin:||Less than 1.0 EU per μg by the LAL method.|
|Purity:||>95% as determined by SDS-PAGE.|
|Storage:||For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
Please avoid repeated freeze-thaw cycles.
No activity loss is observed after storage at:
4-8 centigrade for 12 months in lyophilized state;
-70 centigrade for 3 months under sterile conditions after reconstitution.
|Gene Name:||Tnfsf18 tumor necrosis factor (ligand) superfamily, member 18 [ Mus musculus ]|
|Synonyms:||TNFSF18; tumor necrosis factor (ligand) superfamily, member 18; tumor necrosis factor ligand superfamily member 18; GITR ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced-tumor necrosis factor receptor ligand; Gitrl;|
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