Recombinant Mouse Trim29 Protein, Myc/DDK-tagged

• Cat.No.: Trim29-6650M
• Product Overview: Purified recombinant protein of mouse full-length tripartite motif-containing 29 (Trim29), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Plays a crucial role in the regulation of macrophage activation in response to viral or bacterial infections within the respiratory tract. Mechanistically, TRIM29 interacts with IKBKG/NEMO in the lysosome where it induces its 'Lys-48' ubiquitination and subsequent degradation. In turn, the expression of type I interferons and the production of proinflammatory cytokines are inhibited. Additionally, induces the 'Lys-48' ubiquitination of STING1 in a similar way, leading to its degradation.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 65.8 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Trim29 tripartite motif-containing 29 [ Mus musculus (house mouse) ]
• Official Symbol: Trim29
• Synonyms: TRIM29; tripartite motif-containing 29; tripartite motif-containing protein 29; tripartite motif protein 29; AI119726; 1110047J21Rik; 2810431N19Rik; 4732461M22Rik
• Gene ID: 72169
• mRNA Refseq: NM_023655
• Protein Refseq: NP_076144
• UniProt ID: Q8R2Q0