Recombinant Mouse Tyro3 protein,hIgG&His-tagged

• Cat.No.: Tyro3-23M
• Product Overview: Recombinant Mouse Tyro3 protein,hIgG&His-tagged,expressed in Baculovirus.

Specification

• Species: Mouse
• Source: Insect cells
• Tag: Fc&His
• Protein Length: 31-419 aa
• Description: Tyro3, also known as tyrosine-protein kinase receptor TYRO3 isoform A, is one of the receptor tyrosinekinase subfamily. It transduces signals from the extracellular matrix into the cytoplasm by binding to severalligands including TULP1 or GAS6. This protein regulates many physiological processes including cellsurvival, migration and differentiation. It activates the AKT survival pathway, including nuclear translocation of NF-kappa-B and upregulation of transcription of NF-kappa-B-regulated genes. This protein plays a role invarious processes such as neuron protection from excitotoxic injury, platelet aggregation and cytoskeletonreorganization. Recombinant mouse Tyro3, fused to hIgG-His-tag at C-terminus, was expressed in insect celland purified by using conventional chromatography techniques.
• Source: Insect cells
• Species: Mouse
• Tag: hIgG&His
• Molecular Mass: 68.9 kDa
• AA Sequence: AGLKLMGAPV KMTVSQGQPV KLNCSVEGME DPDIHWMKDG TVVQNASQVS ISISEHSWIG LLSLKSVERS DAGLYWCQVK
  DGEETKISQS VWLTVEGVPF FTVEPKDLAV PPNAPFQLSC EAVGPPEPVT IYWWRGLTKV GGPAPSPSVL NVTGVTQRTE
  FSCEARNIKG LATSRPAIVR LQAPPAAPFN TTVTTISSYN ASVAWVPGAD GLALLHSCTV QVAHAPGEWE ALAVVVPVPP
  FTCLLRNLAP ATNYSLRVRC ANALGPSPYG DWVPFQTKGL APARAPQNFH AIRTDSGLIL EWEEVIPEDP GEGPLGPYKL
  SWVQENGTQD ELMVEGTRAN LTDWDPQKDL ILRVCASNAI GDGPWSQPLV VSSHDHAGRQ GPPHSRTSWEPKSCDKTHT CPPCPAPELL GGPSVFLFPP KPKDTLMISR TPEVTCVVVD VSHEDPEVKF NWYVDGVEVH NAKTKPREEQ
  YNSTYRVVSV LTVLHQDWLN GKEYKCKVSN KALPAPIEKT ISKAKGQPRE PQVYTLPPSR DELTKNQVSL TCLVKGFYPS
  DIAVEWESNG QPENNYKTTP PVLDSDGSFF LYSKLTVDKS RWQQGNVFSC SVMHEALHNH YTQKSLSLSP GKHHHHHH
• Purity: > 95% by SDS-PAGE
• Notes: For research use only. This product is not intended or approved for human, diagnostics or veterinary use.
• Storage: Can be stored at +2C to +8C for 1 week. For long term storage, aliquot and store at -20C to -80C. Avoid repeated freezing and thawing cycles.
• Concentration: 0.25mg/ml (determined by absorbance at 280nm)
• Storage Buffer: Liquid in. Phosphate-Buffered Saline (pH 7.4) containing 10% glycerol
• References: Shao H., et al. (2017) Biochem Biophys Res Commun. 490:1074-1079.
  Blades F., et al. (2018) Glia. 66:2209-2220.

Gene Information

• Gene Name: Tyro3 TYRO3 protein tyrosine kinase 3 [ Mus musculus (house mouse) ]
• Official Symbol: Tyro3
• Synonyms: Tyro3, AI323366, Brt, Dtk, Etk-2, etk2/tyro3, Rse, Sky, Tif, tk19-1, Tyrosine-protein kinasereceptor TYRO3, Etk2/tyro3, Tyrosine-protein kinase DTK, Tyrosine-protein kinase RSE,Tyrosine-protein kinase TIF
• Gene ID: 22174
• mRNA Refseq: NM_019392
• Protein Refseq: NP_062265
• UniProt ID: P55144