Recombinant Mouse Ubash3b Protein, Myc/DDK-tagged

• Cat.No.: Ubash3b-6777M
• Product Overview: Purified recombinant protein of mouse full-length ubiquitin associated and SH3 domain containing, B (Ubash3b), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Species: Mouse
• Source: HEK293
• Tag: DDK&Myc
• Description: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination.
• Molecular Mass: 71.4 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Ubash3b ubiquitin associated and SH3 domain containing, B [ Mus musculus (house mouse) ]
• Official Symbol: Ubash3b
• Synonyms: UBASH3B; ubiquitin associated and SH3 domain containing, B; ubiquitin-associated and SH3 domain-containing protein B; STS-1; T-cell ubiquitin ligand 2; cbl-interacting protein p70; tyrosine-protein phosphatase STS1/TULA2; suppressor of T-cell receptor signaling 1; p70; TULA-2; BB125008; 2810457I06Rik
• Gene ID: 72828
• mRNA Refseq: NM_176860
• Protein Refseq: NP_789830
• UniProt ID: Q8BGG7