Recombinant Mouse Xrn2 Protein, Myc/DDK-tagged

• Cat.No.: Xrn2-7025M
• Product Overview: Purified recombinant protein of Mouse 5'-3' exoribonuclease 2 (Xrn2), with C-terminal MYC/DDK tag, expressed in HEK293T cells.

Specification

• Description: Possesses 5'->3' exoribonuclease activity. May promote the termination of transcription by RNA polymerase II. During transcription termination, cleavage at the polyadenylation site liberates a 5' fragment which is subsequently processed to form the mature mRNA and a 3' fragment which remains attached to the elongating polymerase. The processive degradation of this 3' fragment by this protein may promote termination of transcription. Binds to RNA polymerase II (RNAp II) transcription termination R-loops formed by G-rich pause sites.
• Source: HEK293T
• Species: Mouse
• Tag: Myc/DDK
• Molecular Mass: 108.7 kDa
• Purity: > 80% as determined by SDS-PAGE and Coomassie blue staining
• Stability: Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: Store at -80 centigrade after receiving vials.
• Concentration: >50 μg/mL as determined by microplate BCA method
• Storage Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10% glycerol.

Gene Information

• Gene Name: Xrn2 5'-3' exoribonuclease 2 [ Mus musculus (house mouse) ]
• Official Symbol: Xrn2
• Synonyms: XRN2; 5-3 exoribonuclease 2; protein Dhm1
• Gene ID: 24128
• mRNA Refseq: NM_011917
• Protein Refseq: NP_036047
• UniProt ID: Q9DBR1