Recombinant Rat ADCY10 Protein, His (Fc)-Avi-tagged

• Cat.No.: ADCY10-172R
• Product Overview: Recombinant Rat ADCY10 with His (Fc)-Avi tag was expressed and purified

Specification

• Source: HEK293
• Species: Rat
• Tag: His&Fc&Avi
• Endotoxin: < 1.0 EU per μg of the protein as determined by the LAL method
• Purity: ≥85% by SDS-PAGE
• Stability: Stable for at least 6 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles.
• Storage: For long term storage, aliquot and store at -20 to -80 centigrade. Avoid repeated freezing and thawing cycles.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: Adcy10 adenylate cyclase 10 (soluble) [ Rattus norvegicus ]
• Official Symbol: ADCY10
• Gene ID: 59320
• mRNA Refseq: NM_021684.1
• Protein Refseq: NP_067716.1
• UniProt ID: Q9Z286

Q&As

Can ADCY10 protein be used as a biomarker for cardiovascular disease or other conditions?

While there is some evidence linking ADCY10 protein expression or activity to cardiovascular disease and other conditions, more research is needed to determine its diagnostic or prognostic value as a biomarker. Some recent studies have shown promising results in using ADCY10 expression as a potential biomarker for heart failure and hypertension.

What are the potential therapeutic applications of ADCY10 protein?

The potential therapeutic applications of ADCY10 protein include the treatment of cardiovascular diseases such as heart failure and hypertension. ADCY10 is involved in the signaling pathway that regulates the contraction and relaxation of cardiac muscle, and modulation of its activity could improve cardiac function. Additionally, ADCY10 has been linked to insulin secretion, and targeting its activity could have potential applications in the treatment of diabetes.

Is ADCY10 protein used in diagnostic testing?

ADCY10 protein is not currently used in diagnostic testing, although its expression levels have been studied in various diseases such as heart failure and obesity. Further research is needed to determine its diagnostic value in specific disease contexts.

Are there any drugs currently available that target ADCY10 protein?

There are currently no drugs available that specifically target ADCY10 protein, but some drugs that target the cAMP signaling pathway, which is regulated by ADCY10, are already in clinical use or under development. Examples of these drugs include beta-adrenergic receptor agonists and phosphodiesterase inhibitors.

How might personalized medicine approaches involving ADCY10 protein be developed in the future?

One potential approach to personalized medicine involving ADCY10 protein could involve genetic testing to identify individuals who have variants in the ADCY10 gene that are associated with increased risk of certain conditions. These individuals could then be targeted with personalized therapeutic approaches, such as gene therapy or precision medicine drugs that specifically modulate ADCY10 activity. Additionally, measurement of ADCY10 activity levels in individual patients may help guide treatment decisions and improve treatment effectiveness.

Is ADCY10 protein a viable target for gene therapy?

Gene therapy approaches targeting ADCY10 protein have not yet been extensively investigated, but some recent studies have explored the potential of using viral vectors and other strategies to deliver gene therapy targeting ADCY10 to treat heart failure and other conditions. However, more research is needed to determine the efficacy and safety of these approaches.

What are the challenges to using ADCY10 protein as a therapeutic agent?

One major challenge to using ADCY10 protein as a therapeutic agent is its potential for off-target effects. Since ADCY10 is involved in a complex network of signaling pathways, modulation of its activity could have unintended consequences. Additionally, its tissue-specific expression patterns and potential for functional redundancy with other proteins in its pathway may limit its utility as a therapeutic target. Further research is needed to better understand the potential therapeutic applications of ADCY10 protein and to develop more precise targeting strategies.

Is ADCY10 protein expressed in other tissues besides the heart and pancreas?

Yes, ADCY10 protein is expressed in various tissues besides the heart and pancreas, including the brain, kidneys, and gastrointestinal tract. Its expression patterns vary by tissue, suggesting that it may have tissue-specific functions outside of its well-characterized roles in the cardiovascular and endocrine systems.

Are there any current FDA-approved drugs that target ADCY10?

There are currently no FDA-approved drugs that specifically target ADCY10. However, some existing drugs such as beta-blockers and calcium channel blockers indirectly affect ADCY10 activity by modulating the signaling pathways it is involved in.

How is ADCY10 protein produced for research and therapeutic purposes?

ADCY10 protein can be produced using recombinant DNA technology, which involves cloning and expressing the ADCY10 gene in a host cell such as bacteria or yeast. The protein can then be purified and used for research or therapeutic purposes.

Could modulation of ADCY10 activity have potential applications in other disease areas beyond cardiovascular disease?

Yes, ADCY10 is known to play a role in a variety of physiological processes beyond cardiovascular function, including insulin secretion, immune responses, and neuroendocrine regulation. Modulation of ADCY10 activity could potentially have applications in the treatment of conditions such as diabetes, infectious diseases, and psychiatric disorders.

Can ADCY10 activity be regulated by small molecules or other compounds?

Yes, ADCY10 activity can be regulated by small molecules or other compounds. For example, forskolin, a plant-derived compound, stimulates ADCY10 activity by activating the G protein signaling pathway it is involved in. Other compounds that indirectly affect ADCY10 activity include beta-blockers and calcium channel blockers, which are commonly used to treat cardiovascular diseases.