Recombinant Rhesus macaque IGFBP1 protein, His-tagged

• Cat.No.: IGFBP1-822R
• Product Overview: Recombinant Rhesus macaque IGFBP1 (Ala48-Asn281) protein was fused to His-tag at C-terminus and expressed in human 293 cells (HEK293).

Specification

• Description: Insulin-like growth factor-binding protein 1 (IGFBP1) is also known as placental protein 12 (PP12), which contains oneIGFBP N-terminal domain and one thyroglobulin type-1 domain. IGFBP1 can bindd both insulin-like growth factors (IGFs) I and II and circulates in the plasma. Binding of IGFBP1 can prolongd the half-life of the IGFs and alterd their interaction with cell surface receptors. Furthermore, IGFBP1 can promote cell migration. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.
• Source: HEK293
• Species: Rhesus macaque
• Tag: His
• Predicted N Terminal: Ala48
• Form: Lyophilized from 0.22 μm filtered solution in PBS, pH7.4, 10% trehalose.
• Molecular Mass: The protein has a calculated MW of 27.2 kDa. The protein migrates as 35 kDa under reducing (R) condition (SDS-PAGE).
• Protein length: Ala48-Asn281
• Endotoxin: Less than 1.0 EU per μg by the LAL method.
• Purity: >98% as determined by SDS-PAGE.
• Storage: For long term storage, the product should be stored at lyophilized state at -20 centigrade or lower.
  Please avoid repeated freeze-thaw cycles.
  This product is stable after storage at:
  -20 to -70 centigrade for 12 months in lyophilized state;
  -70 centigrade for 3 months under sterile conditions after reconstitution.
• Reconstitution: It is recommended that sterile water be added to the vial to prepare a stock solution of 0.2 ug/ul. Centrifuge the vial at 4℃ before opening to recover the entire contents.

Gene Information

• Gene Name: IGFBP1
• Official Symbol: IGFBP1
• Synonyms: AFBP; IBP1; PP12; IGF-BP25; hIGFBP-1
• Gene ID: 696994
• mRNA Refseq: XM_001085935.4
• Protein Refseq: XP_001085935.2
• UniProt ID: A0A1D5QTL3

Reviews

06/13/2022

Precise antibody validation, enhances immunoprecipitation studies.

03/12/2019

Efficient protein purification, delivers high yield and purity.

06/25/2018

Dependable expertise in protein engineering, unmatched quality.

Q&As

How does IGFBP1 contribute to the development and progression of cancers, especially hormone-dependent cancers?

IGFBP1 influences the progression of certain cancers, particularly those sensitive to hormonal regulation.

How do changes in IGFBP1 expression affect aging and age-related diseases?

Changes in IGFBP1 expression contribute to the aging process and the development of age-related diseases.

What is the impact of IGFBP1 on fetal growth and development during pregnancy?

IGFBP1 is important for fetal growth and development, regulating growth factor activity during pregnancy.

How does IGFBP1 influence muscle growth and regeneration, particularly in muscle-wasting conditions?

IGFBP1 affects muscle growth and regeneration, playing a role in conditions involving muscle wasting.

What are the effects of IGFBP1 on cardiovascular health and diseases such as atherosclerosis?

IGFBP1 impacts cardiovascular health, influencing factors like blood vessel growth and atherosclerosis development.

What role does IGFBP1 play in metabolic processes, particularly in glucose homeostasis and insulin sensitivity?

IGFBP1 plays a crucial role in glucose metabolism and insulin sensitivity, impacting overall metabolic health.

How does IGFBP1 regulate the activity of insulin-like growth factors (IGFs) in different tissues?

IGFBP1 modulates the availability and activity of IGFs, affecting growth and metabolic functions in various tissues.