Recombinant Rhesus Monkey TNFSF18 Protein

• Cat.No.: TNFSF18-1814R
• Product Overview: Recombinant Rhesus monkey TNFSF18 Protein (Q1PBC4 ( aa.50-177)) was expressed in human HEK293 cells.

Specification

• Species: Rhesus macaque
• Source: HEK293
• Tag: His
• Protein Length: 50-177 a.a.
• Description: GITRL/TNFSF18 is a member of the tumor necrosis factor (TNF) superfamily which is a ligand for receptor TNFRSF18/AITR/GITR. it regulates T-cell responses. Can function as costimulator and lower the threshold for T-cell activation and T-cell proliferation. Important for interactions between activated T-lymphocytes and endothelial cells. Mediates activation of NF-kappa-B. Triggers increased phosphorylation of STAT1 and up-regulates expression of VCAM1 and ICAM1 (PubMed:23892569). Promotes leukocyte adhesion to endothelial cells (PubMed:23892569). Regulates migration of monocytes from the splenic reservoir to sites of inflammation.
• Form: PBS, pH7.4.
• Purity: > 95 %
• Applications: WB; ELISA; Immunogen
• Storage: -80 centigrade, Avoid freeze/thaw cycle.
• Concentration: 1 mg/mL

Gene Information

• Gene Name: TNFSF18 TNF superfamily member 18 [ Macaca mulatta (Rhesus monkey) ]
• Official Symbol: TNFSF18
• Synonyms: TNFSF18; tumor necrosis factor (ligand) superfamily; member 18; tumor necrosis factor ligand superfamily member 18; AITRL; hGITRL; TL6; AITR ligand; GITR ligand; activation-inducible TNF-related ligand; glucocorticoid-induced TNF-related ligand; glucocorticoid-induced TNFR-related protein ligand; GITRL; MGC138237
• Gene ID: 678654
• mRNA Refseq: NM_001040191.1
• Protein Refseq: NP_001035281.1
• UniProt ID: Q1PBC4