Recombinant SARS Coronavirus Spike Glycoprotein Mosaic (S2, S2') protein


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Recombinant SARS Coronavirus Spike Glycoprotein Mosaic (S2, S2') protein

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Cat.No. : Spike-205V
Product Overview : Recombinant SARS Coronavirus Spike Glycoprotein Mosaic (S2, S2') protein was expressed in E.coli. Mosaic protein contains C-terminal section of the Spike protein 1051-1076, 1121-1154, 1162-1190 amino acids immunodominant regions.
Description : Spike protein S2: Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis.
Source : E.coli
Species : SARS-CoV
Form : Liquid. 25mM Tris-HCl, 0.4% sarcosyl, 0.25% Triton X-100 and 50% glycerol.
Molecular Mass : 37 kDa
Purity : >95% as determined by 10% PAGE (coomassie staining).
Applications : ELISA, Western blot.
Storage : Upon arrival, storeat below -18 centigrade.
Shipping : Dry Ice.
Warning : For Research Use Only.
Synonyms : sars2; E2; sars3a
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.

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