Recombinant SARS-CoV-2 S Protein, Fc-tagged

• Cat.No.: S-21S
• Product Overview: Recombinant 2019-nCoV S2 Protein is produced by our Mammalian expression system and the target gene encoding Ser686-Gln1208 is expressed with a Fc tag at the C-terminus.

Specification

• Description: The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. Most notable is severe acute respiratory syndrome (SARS). The severe acute respiratory syndrome-coronavirus (SARS-CoV) spike (S) glycoprotein alone can mediate the membrane fusion required for virus entry and cell fusion. It is also a major immunogen and a target for entry inhibitors. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity.
• Source: Human Cells
• Species: SARS-CoV-2
• Tag: Fc
• Form: Supplied as a 0.2 μm filtered solution of PBS, PH7.4.
• AA Sequence: Ser686-Gln1208
• Endotoxin: NA
• Shipping: Dry ice/ice packs

Gene Information

• Gene Name: S surface glycoprotein [ Severe acute respiratory syndrome coronavirus 2 ]
• Official Symbol: S
• Synonyms: S2 protein; Spike glycoprotein Subunit2; S glycoprotein Subunit2; Spike protein S2; COVID-19
• Gene ID: 43740568
• Protein Refseq: YP_009724390.1
• UniProt ID: P0DTC2