Recombinant SARS-CoV(Beijing 02) S(1-1190) protein
Cat.No. : | SARSS-102V |
Product Overview : | Purified recombinant SARS-CoV(Beijing 02) S(1-1190) protein was expressed in HEK293 cells. |
- Specification
- Gene Information
- Related Products
Description : | Spike protein S1: Attaches the virion to the cell membrane by interacting with host receptor, initiating the infection (By similarity). Binding to human ACE2 and CLEC4M/DC-SIGNR receptors and internalization of the virus into the endosomes of the host cell induces conformational changes in the S glycoprotein. Proteolysis by cathepsin CTSL may unmask the fusion peptide of S2 and activate membranes fusion within endosomes.Spike protein S2: Mediates fusion of the virion and cellular membranes by acting as a class I viral fusion protein. Under the current model, the protein has at least three conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.Spike protein S2': Acts as a viral fusion peptide which is unmasked following S2 cleavage occurring upon virus endocytosis. |
Source : | HEK293 |
Species : | SARS-CoV |
Form : | Each vial contains 100 ug purified protein (1mg/ml) in PBS (pH7.4). |
Purity : | >95% |
Applications : | WB standard, Ab ELISA, immunogen, etc. |
Usage : | For research use only, not for use in diagnostic procedures. |
Storage : | Store at -80 centigrade, Avoid freeze/thaw cycle. |
Concentration : | 1 mg/ml |
Gene Name : | S |
Official Symbol : | S |
Synonyms : | E2 |
Gene ID : | 1489668 |
Protein Refseq : | NP_828851.1 |
UniProt ID : | P59594 |
Products Types
Related Gene
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
Inquiry
0
Inquiry Basket