Recombinant Simian Immunodeficiency Virus VPX Protein (1-112 aa), His-SUMO-tagged

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Recombinant Simian Immunodeficiency Virus VPX Protein (1-112 aa), His-SUMO-tagged

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Cat.No. : VPX-882S
Product Overview : Recombinant Simian Immunodeficiency Virus (isolate K78) (SIV-mac) VPX Protein (1-112 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Protein Description: Full Length.
Description : Plays a role in nuclear translocation of the viral pre-integration complex (PIC), thus is required for the virus to infect non-dividing cells. Targets specific host proteins for degradation by the 26S proteasome. Acts by associating with the cellular CUL4A-DDB1 E3 ligase complex through direct interaction with host VPRPB/DCAF-1. This change in the E3 ligase substrate specificity results in the degradation of host SAMHD1. In turn, SAMHD1 depletion allows viral replication in host myeloid cells by preventing SAMHD1-mediated hydrolysis of intracellular dNTPs necessary for reverse transcription.
Source : E. coli
Species : Simian Immunodeficiency Virus
Tag : His-SUMO
Form : Tris-based buffer, 50% glycerol
Molecular Mass : 29.2 kDa
Protein length : 1-112 aa
AA Sequence : MSDPRERIPP RNSGEETIGE AFEWLNRTVE EINREAVNHL PRELIFQVWQ RSWEYWHDEQ RMSQSYVKYR YLCLMQKALF MHCKKGCRCL GEGHRAGGWR PGPPPPPPPG LA
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with concentration instruction is sent along with the products.
UniProt ID : P11266
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

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