Recombinant Streptococcus Pyogenes SPEB Protein (146-398 aa), His-SUMO-tagged

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Recombinant Streptococcus Pyogenes SPEB Protein (146-398 aa), His-SUMO-tagged

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Cat.No. : SPEB-2163S
Product Overview : Recombinant Streptococcus Pyogenes SPEB Protein (146-398 aa) is produced by E. coli expression system. This protein is fused with a 6xHis-SUMO tag at the N-terminal. Research Area: Microbiology. Protein Description: Full Length of Mature Protein.
Description : Important streptococcal virulence factor which cleaves human fibronectin and degrades vitronectin. Also cleaves human IL1B precursor to form biologically active IL1B. Can induce apoptosis in human monocytes and epithelial cells in vitro, and reduces phagocytic activity in monocytic cells. Thus, may play a role in bacterial colonization, invasion, and inhibition of wound healing.
Source : E. coli
Species : Streptococcus Pyogenes
Tag : His-SUMO
Form : Tris-based buffer,50% glycerol
Molecular Mass : 43.6 kDa
Protein length : 146-398 aa
AA Sequence : QPVVKSLLDS KGIHYNQGNP YNLLTPVIEK VKPGEQSFVG QHAATGCVAT ATAQIMKYHN YPNKGLKDYT YTLSSNNPYF NHPKNLFAAI STRQYNWNNI LPTYSGRESN VQKMAISELM ADVGISVDMD YGPSSGSAGS SRVQRALKEN FGYNQSVHQI NRSDFSKQDW EAQIDKELSQ NQPVYYQGVG KVGGHAFVID GADGRNFYHV NWGWGGVSDG FFRLDALNPS ALGTGGGAGG FNGYQSAVVG IKP
Purity : > 90% as determined by SDS-PAGE.
Notes : Repeated freezing and thawing is not recommended. Store working aliquots at 4 centigrade for up to one week.
Storage : The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20 centigrade/-80 centigrade. The shelf life of lyophilized form is 12 months at -20 centigrade/-80 centigrade.
Concentration : A hardcopy of COA with reconstitution instruction is sent along with the products.
Figure :

(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Gene Name : speB pyrogenic exotoxin B [ Streptococcus pyogenes M1 GAS ]
Official Symbol : SPEB
Synonyms : speB;
Gene ID : 901690
UniProt ID : P0C0J0

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