Recombinant Zebrafish ADRB2A

• Cat.No.: ADRB2A-5944Z
• Product Overview: Recombinant Zebrafish ADRB2A full length or partial length protein was expressed.

Specification

• Source: Mammalian Cells
• Species: Zebrafish
• Tag: His
• Form: Liquid or lyophilized powder
• Endotoxin: < 1.0 eu per μg of the protein as determined by the LAL method.
• Purity: >80%
• Notes: This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications.
• Storage: Store it at +4 oC for short term. For long term storage, store it at -20 oC～-80 oC.
• Storage Buffer: PBS buffer

Gene Information

• Gene Name: adrb2a adrenoceptor beta 2, surface a [ Danio rerio (zebrafish) ]
• Official Symbol: ADRB2A
• Gene ID: 565838
• mRNA Refseq: NM_001102652
• Protein Refseq: NP_001096122
• UniProt ID: I7GPU6

Reviews

11/02/2022

the technical support team provided by the manufacturer has been extremely helpful in resolving any issues that have arisen during the course of my research.

09/17/2020

The purity and stability of the ADRB2A protein are exceptional, ensuring that my research is based on a reliable and consistent protein source.

11/25/2019

Its superior quality guarantees that my results will be highly trustworthy and that my experiments will be successful.

04/20/2019

Their responsive and knowledgeable assistance has been invaluable to the success of my project.

Q&As

How do ADRB2 agonists interact with beta blockers?

Beta blockers are medications that block the effects of beta receptors, including ADRB2 receptors. Therefore, concomitant use of beta blockers and ADRB2 agonists can lead to decreased effectiveness of the ADRB2 agonist and potentially worsen asthma symptoms. However, not all beta blockers are equal in their effects on ADRB2 receptors, and some may be more selective and have less impact on asthma control. Therefore, the use of ADRB2 agonists in patients taking beta blockers should be carefully evaluated and may require adjustment of dosages or medications.

How do ADRB2 agonists differ from other asthma medications?

ADRB2 agonists like albuterol work by directly relaxing the airway smooth muscle and increasing airflow, while other asthma medications such as inhaled corticosteroids and leukotriene modifiers work by reducing inflammation and swelling in the airways. ADRB2 agonists are typically used as rescue medications to provide quick relief of asthma symptoms, while other medications are used as maintenance therapy to prevent exacerbations and improve long-term control.

How are ADRB2 agonists used in the treatment of heart failure?

ADRB2 agonists have been studied as a potential treatment for heart failure, as they can improve cardiac function by increasing contractility and decreasing peripheral resistance. However, their clinical use is limited by their potential adverse effects such as tachycardia, arrhythmias, and hypotension.

How are ADRB2 agonists used in the treatment of obesity?

ADRB2 agonists have been studied as a potential treatment for obesity, as they can increase energy expenditure and promote weight loss. However, their clinical use is limited by their potential adverse effects such as tachycardia, hypertension, and anxiety.

What are some potential future developments in ADRB2 research and treatment?

Future developments in ADRB2 research and treatment may include the identification of new mutations and pathways involved in ADRB2 signaling, the development of more selective and potent ADRB2 agonists, and the use of personalized medicine approaches to optimize treatment for individual patients based on their genetic profile and environmental factors. Additionally, there may be increased focus on understanding the role of ADRB2 in non-respiratory conditions such as cardiovascular disease and metabolic disorders, and the development of novel therapeutic strategies targeting ADRB2 in these contexts.

How are ADRB2 agonists used in the treatment of asthma?

ADRB2 agonists such as albuterol and salbutamol are commonly used in the treatment of asthma to relieve bronchospasms and improve breathing. They work by activating ADRB2 receptors in the lungs, leading to relaxation of the smooth muscles and increased airflow. Short-acting ADRB2 agonists like albuterol are used to provide quick relief of symptoms, while long-acting agonists like salmeterol are used as maintenance therapy.

Can ADRB2 agonists be used during pregnancy?

ADRB2 agonists are generally considered safe for use during pregnancy, especially inhaled formulations which have limited systemic absorption. However, as with any medication use during pregnancy, the potential benefits and risks should be carefully evaluated and discussed with a healthcare provider. Additionally, certain ADRB2 agonists may be preferred over others in certain situations, such as for patients with known cardiac disease or premature labor.

How do ADRB2 antagonists affect the heart?

ADRB2 antagonists, also known as beta-blockers, can affect the heart by decreasing cardiac output and lowering blood pressure. They are commonly used to treat hypertension and certain cardiac arrhythmias, but may also have adverse effects such as bradycardia and heart failure exacerbation.

Are there any clinical implications for ADRB2 mutations?

Yes, there are clinical implications for ADRB2 mutations. For example, certain mutations in the ADRB2 gene have been associated with differential response to ADRB2 agonists like albuterol in patients with asthma, and may affect the efficacy of treatment. Other mutations may be associated with increased risk of diseases such as hypertension, diabetes, and obesity.

What are some drugs that target ADRB2?

Some drugs that target ADRB2 include beta-agonists such as albuterol and salbutamol, which are used to treat asthma and other respiratory diseases. Beta-blockers such as propranolol and metoprolol, which are primarily used to treat hypertension and cardiac arrhythmias, also target ADRB2 but in an antagonistic manner.

How do ADRB2 agonists affect glucose metabolism?

ADRB2 agonists can affect glucose metabolism by activating ADRB2 receptors in the liver, leading to increased glucose release. This can be beneficial for patients with hypoglycemia or insulin resistance, but may also lead to hyperglycemia in some patients. Certain genetic variants in the ADRB2 gene may also affect glucose metabolism and increase the risk of diabetes.

What are common genetic variants found in the ADRB2 protein?

Common genetic variants found in the ADRB2 protein include single nucleotide polymorphisms (SNPs) in the gene that encodes the protein. Some of the most common SNPs are rs1042713, rs1042714, and rs1042717, which have been associated with differences in receptor function and response to agonists such as albuterol.

How are ADRB2 mutations linked to diseases?

Mutations in the ADRB2 gene have been linked to various diseases such as asthma, hypertension, and diabetes. For example, some mutations may alter the structure or function of the receptor, leading to decreased responsiveness to agonists and impaired physiological processes such as bronchodilation and glucose metabolism.

Can genetic testing for ADRB2 mutations be useful in clinical practice?

Genetic testing for ADRB2 mutations may be useful in some clinical settings, such as in patients with asthma who are not responding to standard treatment. However, the clinical utility of such testing is currently limited by factors such as the complexity of gene-environment interactions, the low penetrance of certain mutations, and the lack of targeted therapies for most ADRB2 mutations. Therefore, genetic testing for ADRB2 mutations is not routinely recommended in clinical practice.

Can ADRB2 agonists be used in all patients with asthma?

ADRB2 agonists can be used in most patients with asthma, but there are some exceptions. For example, patients with severe or uncontrolled asthma may require additional medications or different treatment approaches, and should be closely monitored when using ADRB2 agonists due to the risk of adverse effects such as tremors, tachycardia, and hypokalemia. Additionally, patients with certain medical conditions such as cardiac arrhythmias or hyperthyroidism may be at increased risk of adverse effects and should use caution when using ADRB2 agonists.