Recombinant Zebrafish APPB
Cat.No. : | APPB-9410Z |
Product Overview : | Recombinant Zebrafish APPB full length or partial length protein was expressed. |
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Source : | Mammalian Cells |
Species : | Zebrafish |
Tag : | His |
Form : | Liquid or lyophilized powder |
Endotoxin : | < 1.0 eu per μg of the protein as determined by the LAL method. |
Purity : | >80% |
Notes : | This item requires custom production and lead time is between 5-9 weeks. We can custom produce according to your specifications. |
Storage : | Store it at +4 oC for short term. For long term storage, store it at -20 oC~-80 oC. |
Storage Buffer : | PBS buffer |
Gene Name : | appb amyloid beta (A4) precursor protein b [ Danio rerio (zebrafish) ] |
Official Symbol : | APPB |
Gene ID : | 170846 |
mRNA Refseq : | NM_152886 |
Protein Refseq : | NP_690842 |
UniProt ID : | Q8UUR9 |
Products Types
◆ Recombinant Protein | ||
APPB-1617B | Recombinant Bacillus subtilis APPB protein, His-tagged | +Inquiry |
For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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Q&As (21)
Ask a questionIn Alzheimer's disease, the APPB protein accumulates in the brain, forming amyloid plaques that can disrupt normal cellular function and contribute to the neurodegenerative processes seen in the disease.
Currently, detection of APPB protein is not used as a routine diagnostic test for Alzheimer's disease. Instead, other biomarkers like amyloid PET scans or cerebrospinal fluid analysis are commonly employed.
Promising treatment strategies being explored include anti-amyloid antibodies that can bind to APPB and facilitate its clearance, inhibitors targeting enzymes involved in APP processing, modulators of APPB production or aggregation, and approaches to enhance the clearance of APPB from the brain.
While the accumulation of APPB protein is primarily associated with Alzheimer's disease, it has also been observed in other neurodegenerative disorders, such as Down syndrome and cerebral amyloid angiopathy.
Yes, various therapeutic strategies aim to reduce the production or accumulation of the APPB protein, such as antibodies targeting APPB or enzymes involved in its production. These approaches are being investigated as potential treatments for Alzheimer's disease.
APPB protein can affect synaptic function through multiple mechanisms. Its accumulation can lead to disruption of normal synaptic signaling pathways, impair neurotransmitter release, alter synaptic plasticity, and increase the vulnerability of synapses to oxidative stress and inflammation, ultimately leading to synaptic dysfunction in Alzheimer's disease.
Some studies suggest that certain lifestyle factors, such as regular physical exercise, healthy diet, and cognitive stimulation, may have a protective effect against Alzheimer's disease by reducing the levels of APPB protein. However, more research is needed to confirm these associations and determine the optimal lifestyle interventions.
While the APPB protein is primarily associated with Alzheimer's disease, it has also been implicated in other neurodegenerative disorders such as cerebral amyloid angiopathy (CAA) and Down syndrome. In CAA, the accumulation of amyloid plaques made up of APPB protein in the blood vessels of the brain can lead to hemorrhages. In individuals with Down syndrome, who have an extra copy of the APP gene, there is an increased production of APPB leading to early-onset Alzheimer's symptoms.
Yes, there are known genetic mutations in the APP gene that can affect the production or processing of APPB protein. Certain mutations in the APP gene can lead to increased production of APPB or the formation of abnormal forms of APP that are more prone to aggregation. These mutations have been found in individuals with familial Alzheimer's disease, an inherited form of the disease that typically manifests at a younger age.
Several environmental and lifestyle factors have been implicated in affecting the production or accumulation of APPB protein. Chronic oxidative stress, inflammation, and certain environmental toxins have been shown to increase APP cleavage and APPB production. Additionally, factors such as a sedentary lifestyle, chronically high levels of stress, and poor sleep quality may also contribute to increased APPB accumulation and aggregation.
Age is the most significant risk factor for developing Alzheimer's disease. Inheriting certain genetic mutations or having a family history of early-onset Alzheimer's can also increase the risk. However, the specific relationship between the APPB protein and these risk factors is still being studied.
The accumulation of APPB protein in the brain leads to the formation of toxic aggregates called amyloid plaques. These plaques can induce neuroinflammation, oxidative stress, synaptic dysfunction, and ultimately neuronal death, contributing to the neurodegenerative process seen in Alzheimer's disease.
Yes, mutations in the APP gene can alter the processing of APP, leading to increased production or altered clearance of the APPB protein. Certain mutations are associated with early-onset familial Alzheimer's disease.
The presence of APPB protein in the brain can contribute to neuronal cell death in Alzheimer's disease through several mechanisms. The accumulation of APPB and its aggregation into amyloid plaques can trigger inflammation and oxidative stress, which can lead to the death of neurons. Additionally, APPB can interfere with normal cellular processes and disrupt synaptic function, ultimately resulting in neuronal dysfunction and death.
Yes, there are several clinical trials underway investigating therapeutic approaches aimed at reducing APPB levels or preventing its aggregation. These trials include antibody-based therapies, immune modulators, and small molecule inhibitors targeting the production or clearance of APPB. Clinical trials are also exploring combination therapies to target multiple aspects of the disease pathology.
Yes, the APPB protein exists in different isoforms, including Aβ40 and Aβ42. Aβ42 is considered more amyloidogenic and more likely to form the amyloid plaques associated with Alzheimer's disease.
Several promising biomarkers associated with APPB protein are being investigated for early detection of Alzheimer's disease. These include measuring levels of APPB or its precursor in cerebrospinal fluid or through blood-based assays, as well as novel imaging techniques that can directly visualize APPB pathology in the brain. However, further research is needed to validate and refine these biomarkers for clinical use.
The APPB protein's exact functions are still not fully understood. However, it is believed to play a role in neuronal development, cell signaling, synaptic plasticity, and regulation of iron homeostasis.
While lifestyle modifications alone may not directly reduce the levels of APPB protein, adopting a healthy lifestyle can potentially reduce the overall risk of developing Alzheimer's disease. Regular physical exercise, a balanced diet, mental stimulation, and adequate sleep have been associated with a reduced risk of cognitive decline and may indirectly impact the levels of APPB protein by promoting overall brain health.
Targeting the APPB protein is indeed a potential therapeutic approach for treating Alzheimer's disease. By reducing the levels of APPB or preventing its aggregation, it may be possible to slow down or halt the progression of the disease. Several ongoing clinical trials are testing different strategies to target APPB, including immunotherapies, enzyme inhibitors, and other small molecule compounds.
Currently, imaging techniques like amyloid PET scans can indirectly detect the presence of amyloid plaques in the brain, which are composed of the APPB protein. These scans help in assessing the amyloid burden and ruling out other causes of cognitive decline.
Customer Reviews (4)
Write a reviewThe APPB protein offers exceptional quality that meets the rigorous demands of experimental research.
What sets the APPB protein apart is not only its outstanding quality but also the excellent technical support provided by the manufacturer.
Its purity, consistency, and reliable performance make it a top choice for a wide range of applications.
Whether studying angiopoietin signaling pathways, vascular remodeling, or endothelial cell biology, the APPB protein is an invaluable tool for researchers.
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