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STAT1

  • Official Full Name

    signal transducer and activator of transcription 1, 91kDa

  • Overview

    The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors,;STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that;translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various;ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a;variety of genes, which is thought to be important for cell viability in response to different cell stimuli and;pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
  • Synonyms

    STAT1; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1-alpha/beta; ISGF 3; STAT91; transcription factor ISGF 3 components p91/p84; transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription-1; CANDF7; ISGF-3; DKFZp686B04100;

  • Recombinant Proteins
  • Cell & Tissue Lysates
  • Protein Pre-coupled Magnetic Beads
  • Chicken
  • Human
  • Mouse
  • Rhesus Macaque
  • E.coli
  • HEK293
  • HEK293T
  • Insect Cell
  • Insect Cells
  • Mammalian Cell
  • Mammalian cells
  • Sf21 Insect Cell
  • Sf9 Insect Cell
  • Flag
  • GST
  • His
  • His (Fc)
  • Avi
  • His|MBP
  • His|T7
  • Myc
  • DDK
  • Myc|DDK
  • N/A
  • N
Species Cat.# Product name Source (Host) Tag Protein Length Price
Human STAT1-8473H Active Recombinant Human STAT1, His-tagged Sf21 Insect Cell His
Human STAT1-1164H Active Recombinant Human STAT1 Sf9 Insect Cell N/A
Human STAT1-7037H Recombinant Human STAT1 protein(Met1-Val712), His&GST-tagged Insect Cells N-His&GST Met1-Val712
Human STAT1-2996H Recombinant Human STAT1 protein, GST-tagged E.coli GST 2-230 aa
Human STAT1-73H Recombinant Human STAT1, no tag E.coli N/A
Human STAT1-30903TH Recombinant Human STAT1 N/A
Human STAT1-040H Recombinant Human STAT1 Protein E.coli N/A
Human STAT1-331H Recombinant Human STAT1 protein, His/MBP-tagged E.coli His/MBP 509-735 aa
Human STAT1-2783H Recombinant Human STAT1, His-tagged E.coli His
Human STAT1-4885H Recombinant Human Signal Transducer And Activator Of Transcription 1, 91kDa, GST-tagged Sf9 Insect Cell GST
Human STAT1-30902TH Recombinant Human STAT1 E.coli N/A
Human STAT1-555HCL Recombinant Human STAT1 cell lysate Insect Cell N/A
Human STAT1-2741H Recombinant Human STAT1 Protein, His-tagged E.coli N-His Ser2-Ala230
Human STAT1-2901H Recombinant Human STAT1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
Human STAT1-4597H Recombinant Human STAT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human STAT1-232HFL Active Recombinant Full Length Human STAT1 Protein, C-Flag-tagged Mammalian cells Flag
Human STAT1-2115H Recombinant Human STAT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Human STAT1-2115H-B Recombinant Human STAT1 Protein Pre-coupled Magnetic Beads HEK293
Human STAT1-5249H Recombinant Human STAT1 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
Human STAT1-6359H Recombinant Human STAT1 Protein (Met1-Arg683), N-His tagged E.coli N-His Met1-Arg683
Human STAT1-01H Recombinant Human STAT1 Protein, GST-tagged Insect Cell GST
Mouse Stat1-1733M Recombinant Mouse Stat1 protein, His & T7-tagged E.coli His/T7 Ser432~Tyr680 (Accession # P42225)
Mouse Stat1-6168M Recombinant Mouse Stat1 Protein, Myc/DDK-tagged HEK293T Myc/DDK
Rhesus Macaque STAT1-4516R Recombinant Rhesus monkey STAT1 Protein, His-tagged Mammalian Cell His
Rhesus Macaque STAT1-4332R Recombinant Rhesus Macaque STAT1 Protein, His (Fc)-Avi-tagged HEK293 His (Fc)-Avi
Rhesus Macaque STAT1-4332R-B Recombinant Rhesus Macaque STAT1 Protein Pre-coupled Magnetic Beads HEK293
Chicken STAT1-2129C Recombinant Chicken STAT1 Mammalian Cell His
  • Involved Pathway
  • Protein Function
  • Interacting Protein
  • Other Resource
  • STAT1 Related Signal Pathway

STAT1 involved in several pathways and played different roles in them. We selected most pathways STAT1 participated on our site, such as Chemokine signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with STAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

Pathway Name Pathway Related Protein
Chemokine signaling pathwayRAC1;RAF1;GNB4;NRAS;GM13306;MAPK3;PIK3CG;Ccl12;ROCK1
Osteoclast differentiationRELA;NCF4;IFNAR2;IL1B;MAPK1;NCF1;cgr2b;PPARG;TNFRSF11B
Toll-like receptor signaling pathwayMAPK8;TICAM2;IFNA1;Ifna11;TLR7;STAT1;IKBKG;MAP2K7;CRFB2
Jak-STAT signaling pathwayEPOR;IL21R;STAT4;SOCS3B;PIK3CD;GHR;AKT1;GM-CSF;PIK3CB
Prolactin signaling pathwayESR1;MAPK12;NFKB1;PRLR;MAPK11;RELA;PRP2;SLC2A2;ESR2
Thyroid hormone signaling pathwayPIK3CB;THRA;PLCD1;MED1;PFKFB2;ATP1B1;ITGAV;AKT2;NOTCH2
LeishmaniasisNFKBIA;HLA-DPA1;NCF1;TGFB3;FCGR1;C3;HLA-DQA2;CYBA;PTPN6
ToxoplasmosisAKT1;MAPK9;MAPK10;HLA-DOB;BIRC3;MAPK12;LAMA4;LAMA3;IFNGR2
TuberculosisCALM3;HLA-DPA1;HLA-DRB5;APAF1;CARD9;PPP3R2;ATP6V0C;CASP8;IFNA4
Hepatitis CSCARB1;IFNA14;PIK3CA;EIF3E;PIK3CB;MAPK3;PIK3R5;IKBKE;TBK1
Hepatitis BTGFB3;RELA;IRF7;CXCL8;TRP53;FOS;STAT2;IFNA8;STAT4
MeaslesIfna15;IFNGR2;AKT1;IRF3;HSPA2;IFNAR2;cgr2b;STAT5B;IFNAR1
Influenza AKPNA1;IKBKE;PML;DNAJC3;KPNA2;PIK3CB;RSAD2;TNFSF10;HLA-DRB3
Herpes simplex infectionCD74A;PVRL1;PPP1CAB;PILRA;TLR3;SRSF1;HCFC1A;PER2;C1QBP
Pathways in cancerMAX;SPI1;FASLG;AXIN1;GNG11;LPAR4;MAP2K1;Adcy4;MET
Pancreatic cancerRALB;TGFBR1;ARAF;MAPK9;SMAD4;STAT3;RAC1;ERBB2;AKT1
Inflammatory bowel disease (IBD)GATA3;STAT6;STAT4;IL1B;IL23;H2-AB1;Il23a;STAT3;HLA-DPA1

STAT1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by STAT1 itself. We selected most functions STAT1 had, and list some proteins which have the same functions with STAT1. You can find most of the proteins on our site.

Function Related Protein

STAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with STAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of STAT1.

STAT2; IFNGR1; EGFR

Gene Family

Cytokines

Research Area

Related articles

Li, J; Jie, HB; et al. PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment. CANCER RESEARCH 75:508-518(2015).
Matsushita, H; Hosoi, A; et al. Cytotoxic T Lymphocytes Block Tumor Growth Both by Lytic Activity and IFN gamma-Dependent Cell-Cycle Arrest. CANCER IMMUNOLOGY RESEARCH 3:26-36(2015).
  • Q&As
  • Reviews

Q&As (6)

Ask a question
What is the function of the STAT1 protein? 12/23/2019

STAT1 is a signal transduction and transcriptional activator involved in regulating a variety of biological processes such as cell growth, differentiation, apoptosis, and immune response.

Are mutations in genes associated with the STAT1 protein related to human disease? 09/21/2019

Mutations in the STAT1 gene have been found to be associated with a variety of diseases, including autoimmune diseases, primary immunodeficiency diseases, and malignant tumors.

What is the signaling pathway of STAT1 protein in immune cells? 09/01/2019

The STAT1 protein is primarily activated by the JAK-STAT signaling pathway. When activated by the receptor, JAK kinase phosphorylates the STAT1 protein, allowing it to form dimers and enter the nucleus to regulate transcription of related genes.

In which diseases does the STAT1 protein play an important role in the development of diseases? 07/16/2019

The STAT1 protein plays an important role in many diseases, including tumors, immune-related diseases (such as immunodeficiency diseases, autoimmune diseases), infectious diseases (such as viral infections), etc.

Are there activators or inhibitors of the STAT1 protein? 06/19/2019

Some activators or inhibitors of the STAT1 protein have been identified. These compounds can be used to study the function of the STAT1 protein and the development of disease treatments.

Is the STAT1 protein involved in the immune response to viral infection? 02/24/2019

The STAT1 protein plays an important role in viral infection. It mediates interferon signaling, promotes antiviral immune responses, and inhibits viral replication and transmission.

Customer Reviews (3)

Write a review
Reviews
04/22/2020

    It is well suited for our laboratory to induce specific immune responses.

    11/26/2019

      It has great application potential and performs well in all aspects.

      04/16/2019

        This protein has high yield and high purity, which greatly improves our production efficiency.

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