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Official Full Name signal transducer and activator of transcription 1, 91kDa
Background The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors,;STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that;translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various;ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a;variety of genes, which is thought to be important for cell viability in response to different cell stimuli and;pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described.
Synonyms STAT1; signal transducer and activator of transcription 1, 91kDa; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription 1-alpha/beta; ISGF 3; STAT91; transcription factor ISGF 3 components p91/p84; transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription-1; CANDF7; ISGF-3; DKFZp686B04100
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • Insect Cell
    • Mammalian Cell
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Tag :
    • GST
    • His
    • MBP
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human STAT1-040H Recombinant Human STAT1 Protein E.coli N/A
    Human STAT1-1164H Recombinant Human STAT1 Sf9 Insect Cell N/A
    Human STAT1-2783H Recombinant Human STAT1, His-tagged E.coli His
    Human STAT1-2901H Recombinant Human STAT1 Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human STAT1-2996H Recombinant Human STAT1, GST-tagged E.coli GST
    Human STAT1-30902TH Recombinant Human STAT1 E.coli N/A
    Human STAT1-30903TH Recombinant Human STAT1 N/A
    Human STAT1-331H Recombinant Human STAT1 protein, His/MBP-tagged E.coli His/MBP
    Human STAT1-4885H Recombinant Human Signal Transducer And Activator Of Transcription 1, 91kDa, GST-tagged Sf9 Insect Cell GST
    Human STAT1-555HCL Recombinant Human STAT1 cell lysate Insect Cell N/A
    Human STAT1-7037H Recombinant Human STAT1, His & GST tagged Insect Cell His/GST
    Human STAT1-73H Recombinant Human STAT1, no tag E.coli N/A
    Human STAT1-8473H Recombinant Human STAT1, His-tagged Sf21 Insect Cell His
    Mouse Stat1-1733M Recombinant Mouse Stat1 protein, His & T7-tagged E.coli His/T7
    Rhesus Macaque STAT1-4516R Recombinant Rhesus monkey STAT1 Protein, His-tagged Mammalian Cell His
    Chicken STAT1-2129C Recombinant Chicken STAT1 Mammalian Cell His

    stat1 involved in several pathways and played different roles in them. We selected most pathways stat1 participated on our site, such as Chemokine signaling pathway, Osteoclast differentiation, Toll-like receptor signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with stat1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Chemokine signaling pathway CXCL8; ADRBK2; SRC; GM1987; CCL21B; CCL17; CXCL6; ELMO1; PRKCD; NFKB1
    Osteoclast differentiation STAT2; FCGR1A; MAP2K1; TGFBR2; MAPK11; PPP3CA; SOCS3; FCGR1; NCF4; LILRB1
    Toll-like receptor signaling pathway PIK3CG; MAPK3; MAPK12A; IL12A; MAPK12B; NFKBIAA; IL8L1; TLR9; CCL5; TLR2
    Jak-STAT signaling pathway BCL2L1; M17; IL10RB; HRASB; STAT4; IL5RA; Ifna11; CSF3R; Ifnl2; PIK3R1
    Prolactin signaling pathway SHC2; TH; RELA; MAPK9; SOS1; LHCGR; MAPK8; PIK3R5; AKT2; SOCS7
    Thyroid hormone signaling pathway EP300; MED4; RHEB; MED27; ITGB3; PRKACA; HDAC1; PLCD1; THRA; ATP1B4
    Leishmaniasis MAPK1; FCGR2C; STAT1; FCGR1A; NCF4; IFNGR2; FCGR1; IL1A; Itgam&Itgb2; MAP3K7
    Tuberculosis IL12A; CALM1; PPP3CC; BCL10; AKT1; FCGR2C; ATP6V0B; MAPK11; ARHGEF12; ATP6V0A4
    Hepatitis B IL6; ATP6AP1; NFATC3; TRP53; IFNA14; RB1; TGFB1; IFNA8; Fasl; STAT1
    Measles IFNA14; IFNA7; OAS1A; IRAK4; IL12B; EIF2AK2; IFIH1; IFNA16; FCGR2B; HSPA1B
    Influenza A MAP2K4; NXT1; OAS1; H2-AA; PIK3R3; NFKBIA; MAPK8; TNFSF10; MAPK11; NXF3
    Herpes simplex infection TAF4B; BF2; TAF3; SRSF3; TBPL2; SRSF6; MHC2DEB; TAB2; EP300; IL12BA
    Pathways in cancer BIRC7; FZD2; Adcy4; FGFR2; FZD5; PPARD; PIK3R3; PTGER4; HGF; PDGFB
    Pancreatic cancer MAPK1; BRCA2; TGFBR1; PIK3CD; STAT3; BAD; TRP53; AKT1; PIK3CG; CDC42
    Inflammatory bowel disease (IBD) H2-AB1; HLA-DQA1; NFKB1; TBX21; STAT3; HLA-DPA1; HLA-DMA; HLA-DRB1; IL4R; IL12A

    stat1 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by stat1 itself. We selected most functions stat1 had, and list some proteins which have the same functions with stat1. You can find most of the proteins on our site.

    Function Related Protein

    stat1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with stat1 here. Most of them are supplied by our site. Hope this information will be useful for your research of stat1.


    Li, J; Jie, HB; et al. PD-1/SHP-2 Inhibits Tc1/Th1 Phenotypic Responses and the Activation of T Cells in the Tumor Microenvironment. CANCER RESEARCH 75:508-518(2015).
    Matsushita, H; Hosoi, A; et al. Cytotoxic T Lymphocytes Block Tumor Growth Both by Lytic Activity and IFN gamma-Dependent Cell-Cycle Arrest. CANCER IMMUNOLOGY RESEARCH 3:26-36(2015).

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