acvr2b
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  • Official Full Name
  • activin A receptor, type IIB
  • Background
  • Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
  • Synonyms
  • ACVR2B; activin A receptor, type IIB; ACTRIIB; ActR-IIB; HTX4
Cat.#:ACVR2B-011MTag:Fc
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ACVR2B Protein, Fc-tagged
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Cat.#:ACVR2B-1155HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR2B Protein, MYC/DDK-tagged
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Cat.#:Acvr2b-295MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Acvr2b Protein, His-tagged
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Cat.#:Acvr2b-296RTag:His
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Acvr2b Protein, His-tagged
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Cat.#:ACVR2B-196HTag:Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR2B, Fc tagged
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Cat.#:ACVR2B-197HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR2B, His tagged
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Cat.#:ACVR2B-198HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR2B Protein, His-tagged
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Cat.#:ACVR2B-257HTag:GST
Source (Host):Insect CellSpecies:Human
Product nameRecombinant Human ACVR2B Protein, GST-tagged
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Cat.#:ACVR2B-258HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human ACVR2B Protein, GST-tagged
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Cat.#:ACVR2B-29HTag:Flag
Source (Host):Insect cellSpecies:Human
Product nameRecombinant Human ACVR2B protein, Flag-tagged, Biotinylated
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Cat.#:ACVR2B-498HTag:HIgG1/His
Source (Host):NS0Species:Human
Product nameRecombinant Human ACVR2B protein, HIgG1/His-tagged
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Cat.#:ACVR2B-499HTag:HIgG1/His
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human ACVR2B protein, HIgG1/His-tagged
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Cat.#:ACVR2B-533HTag:Fc
Source (Host):Human cellsSpecies:Human
Product nameRecombinant Human ACVR2B, Fc-tagged, Biotinylated
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Cat.#:ACVR2B-6995HTag:GST
Source (Host):Sf 9 Insect cellsSpecies:Human
Product nameRecombinant Human ACVR2B, GST-tagged
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Cat.#:ACVR2B-885HTag:Fc/His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human ACVR2B Protein, Fc/His-tagged
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Cat.#:ACVR2B-886HTag:His
Source (Host):HEK293 cellsSpecies:Human
Product nameRecombinant Human ACVR2B Protein, His-tagged
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Cat.#:ACVR2B-198MTag:FC/His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ACVR2B, Fc-His tagged
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Cat.#:Acvr2b-424MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse Acvr2b, His tagged
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Cat.#:ACVR2B-495RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat ACVR2B Protein
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Cat.#:ACVR2B-193CTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVR2B
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Cat.#:ACVR2B-63CTag:FC/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVR2B, Fc tagged
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Cat.#:ACVR2B-64CTag:FC/His
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVR2B, His tagged
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Cat.#:ACVR2B-5890CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken ACVR2B
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Cat.#:ACVR2B-8811ZTag:His
Source (Host):Mammalian CellsSpecies:Zebrafish
Product nameRecombinant Zebrafish ACVR2B
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Cat.#:ACVR2B-1586HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Activin A Receptor, Type IIB
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Cat.#:ACVR2B-938HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human Activin A Receptor, Type IIB, His-tagged
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Cat.#:ACVR2B-2724HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human ACVR2B cell lysate
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Cat.#:ACVR2B-2540MCLTag:
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse ACVR2B cell lysate
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Cat.#:ACVR2B-734CCLTag:
Source (Host):HEK293Species:Cynomolgus Monkey
Product nameRecombinant Cynomolgus ACVR2B cell lysate
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Cat.#:ACVR2B-P014HTag:Fc
Source (Host):Species:Human
Product nameRecombinant Human ACVR2B, Fc-tagged therapeutic protein
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Involved Pathway

ACVR2B involved in several pathways and played different roles in them. We selected most pathways ACVR2B participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Cytokine-cytokine receptor interaction
EDAR; TNFRSF21; TNFRSF10A; Il6ra; Ifna15; IL26; CCR1L1; GM2506; TP-1; IL3
TGF-beta signaling pathway
MYCB; TGIF2; RHOAD; NDR1; PPP2CB; NBL1; SMAD1; ACVR1BA; INHBA; BMPR2B
Signaling pathways regulating pluripotency of stem cells
FZD5; ISL1; HNF1A; INHBE; FZD6; BMP2; BMI1; SOX2; MAPK1; AXIN2

Protein Function

ACVR2B has several biochemical functions, for example, ATP binding, activin binding, contributes_to activin receptor activity, type II. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR2B itself. We selected most functions ACVR2B had, and list some proteins which have the same functions with ACVR2B. You can find most of the proteins on our site.
Function
Related Protein
Function ATP binding
Related Protein SKIV2L; NME3; HELQ; SARS; ABCG2D; MCCC2; RHOBTB3; RFC5; MAP2K7; ABCG3
Function activin binding
Related Protein SMAD7; ACVR2B; ENG; TGFBR3; FSTL3; FST; ACVR1; ACVRL1; SMURF1; FKBP1A
Function contributes_to activin receptor activity, type II
Related Protein ACVR2B
Function growth factor binding
Related Protein RHBDF1; HTRA1A; HTRA1B; TEK; ACVR1C; SDCBP; ERBB3; IGFBP2A; IGFBP2B; NRP2
Function metal ion binding
Related Protein PCXB; PHYHD1; CDC7; DNTT; MORC4; RFPL4; TRIM55A; RCV1; DGKAA; IRF2BP1
Function protein binding
Related Protein CDC20B; PAGE5; MSH4; TGFBR3; MAPRE1; ERCC8; UCHL5; NCBP2; TCEB3B; SYT11
Function protein serine/threonine kinase activity
Related Protein ACVR1L; ACVR2A; RPS6KAL; NEK7; ATM; HIPK4; SRPK1B; BMPR1AA; TBK1; MAP3K13
Function protein serine/threonine/tyrosine kinase activity
Related Protein MAP2K2; RPS6KB1; DYRK1A; TNK2; DYRK1AA; TESK1; TESK2; DYRK3; DYRK4; MAP2K1
Function receptor signaling protein serine/threonine kinase activity
Related Protein BMPR1AB; TGFBR2; AMHR2; ACVRL1; PAK2B; ACVR1B; SBK3; STK24A; BMPR1A; SLKA

Interacting Protein

ACVR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR2B.
MSTN; Mstn; GDF11; FSTL1; INHBA; HSP90AB1; linkable pd173955 analogue; bosutinib; dasatinib