ACVR2B

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ACVR2B

Official Full Name activin A receptor, type IIB
Background Activin receptor type-2B is a protein that in humans is encoded by the ACVR2B gene. ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor.
Synonyms ACVR2B; activin A receptor, type IIB; ACTRIIB; ActR-IIB; HTX4
    • Species :
    • Chicken
    • Cynomolgus Monkey
    • Human
    • Mouse
    • Rat
    • Zebrafish
    • Source :
    • E.coli
    • HEK293
    • HEK293T
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • NS0
    • Sf21 Insect Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • Fc
    • His
    • Flag
    • GST
    • HIgG1
    • MYC/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse ACVR2B-011M Recombinant Mouse ACVR2B Protein, Fc-tagged HEK293 Fc
    Human ACVR2B-3284H Recombinant Human ACVR2B Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Mouse Acvr2b-529M Recombinant Mouse Acvr2b Protein, MYC/DDK-tagged HEK293T MYC/DDK
    Human ACVR2B-1155H Recombinant Human ACVR2B Protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human ACVR2B-1586H Recombinant Human Activin A Receptor, Type IIB Sf21 Insect Cell N/A
    Human ACVR2B-196H Recombinant Human ACVR2B, Fc tagged Human Cell Fc
    Human ACVR2B-197H Recombinant Human ACVR2B, His tagged Human Cell His
    Human ACVR2B-198H Recombinant Human Activin ACVR2B protein, His-tagged HEK293 His
    Human ACVR2B-257H Recombinant Human ACVR2B Protein, GST-tagged Insect Cell GST
    Human ACVR2B-258H Recombinant Human ACVR2B Protein, GST-tagged Wheat Germ GST
    Human ACVR2B-2724HCL Recombinant Human ACVR2B cell lysate Human Cell N/A
    Human ACVR2B-29H Recombinant Human ACVR2B protein, Flag-tagged, Biotinylated Insect Cell Flag
    Human ACVR2B-498H Recombinant Human ACVR2B protein, HIgG1/His-tagged NS0 HIgG1/His
    Human ACVR2B-499H Recombinant Human ACVR2B protein, HIgG1/His-tagged Insect Cell HIgG1/His
    Human ACVR2B-533H Recombinant Human ACVR2B, Fc-tagged, Biotinylated Human Cell Fc
    Human ACVR2B-6995H Recombinant Human ACVR2B, GST-tagged Sf9 Insect Cell GST
    Human ACVR2B-885H Recombinant Human ACVR2B Protein, Fc/His-tagged HEK293 Fc/His
    Human ACVR2B-886H Recombinant Human ACVR2B Protein, His-tagged HEK293 His
    Human ACVR2B-938H Recombinant Human Activin A Receptor, Type IIB, His-tagged HEK293 His
    Human ACVR2B-P014H Recombinant Human ACVR2B, Fc-tagged therapeutic protein Fc
    Mouse ACVR2B-198M Recombinant Mouse ACVR2B, Fc-His tagged Human Cell Fc/His
    Mouse ACVR2B-2540MCL Recombinant Mouse ACVR2B cell lysate Human Cell N/A
    Mouse Acvr2b-295M Recombinant Mouse Acvr2b Protein, His-tagged E.coli His
    Mouse Acvr2b-424M Recombinant Mouse Acvr2b, His tagged Human Cell His
    Rat Acvr2b-296R Recombinant Rat Acvr2b Protein, His-tagged E.coli His
    Rat ACVR2B-495R Recombinant Rat ACVR2B Protein Mammalian Cell His
    Cynomolgus Monkey ACVR2B-193C Recombinant Cynomolgus ACVR2B Human Cell N/A
    Cynomolgus Monkey ACVR2B-63C Recombinant Cynomolgus ACVR2B, Fc tagged Human Cell Fc/His
    Cynomolgus Monkey ACVR2B-64C Recombinant Cynomolgus ACVR2B, His tagged Human Cell Fc/His
    Cynomolgus Monkey ACVR2B-734CCL Recombinant Cynomolgus ACVR2B cell lysate Human Cell N/A
    Chicken ACVR2B-5890C Recombinant Chicken ACVR2B Mammalian Cell His
    Zebrafish ACVR2B-8811Z Recombinant Zebrafish ACVR2B Mammalian Cell His

    ACVR2B involved in several pathways and played different roles in them. We selected most pathways ACVR2B participated on our site, such as Cytokine-cytokine receptor interaction, TGF-beta signaling pathway, Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with ACVR2B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Cytokine-cytokine receptor interaction EGFRA; IL21; LOC100033925; LIFR; CCL21; TNFRSF10A; PDGFA; TNFSF11; BMP7B; GHRA
    TGF-beta signaling pathway RHOAA; GDF5; SMAD7; ZFYVE9; TGIF1; AMH; TGFBR2; BMP2; BMPR1A; BMPR2A
    Signaling pathways regulating pluripotency of stem cells WNT11; BMPR2; FZD7; LHX5; GSK3B; FGFR2; MAPK13; HAND1; WNT16; WNT7B

    ACVR2B has several biochemical functions, for example, ATP binding, activin binding, contributes_to activin receptor activity, type II. Some of the functions are cooperated with other proteins, some of the functions could acted by ACVR2B itself. We selected most functions ACVR2B had, and list some proteins which have the same functions with ACVR2B. You can find most of the proteins on our site.

    Function Related Protein
    ATP binding STK32C; GRK1; NTRK2; TNK1; HSP90AB1; AKT1; AARS2; CDK1; DGUOK; GRK7A
    activin binding FST; FSTL3; TGFBR3; SMAD7; ENG; SMURF1; ACVR2B; FKBP1A; ACVRL1; ACVR1
    contributes_to activin receptor activity, type II ACVR2B
    growth factor binding NKD2; TEK; HTRA1A; ACVR2B; ACVR2A; SDCBP; LTBP2; HTRA1B; RHBDF2; ACVR1C
    metal ion binding ZNF507; ZFP92; ZDHHC13; ZFP771; MAT2AL; TPH1B; SALL3B; IRGF4; IKZF3; COL27A1B
    protein binding GPBP1; ARHGEF6; RPL13; IGF1R; SLC6A4; CASC3; RYBP; DPEP1; ACTA1; PPP1R16B
    protein serine/threonine kinase activity TGFBR1A; DCLK3; GRK1B; BMPR1B; DSTYK; MAP2K1; CSNK1DA; EIF2AK2; LMTK2; ROCK2B
    protein serine/threonine/tyrosine kinase activity PRKACA; MAP2K2; MAP2K1; RPS6KB1; PRKCG; AKT1; DYRK2; CLK3; TTK; SGK1
    receptor signaling protein serine/threonine kinase activity BMPR1AB; ACVR1B; BMPR2B; TGFBR2; ALPK2; TGFBR1; BMPR2A; STK25B; STK24A; BMPR1BA

    ACVR2B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with ACVR2B here. Most of them are supplied by our site. Hope this information will be useful for your research of ACVR2B.

    MSTN; Mstn; GDF11; FSTL1; INHBA; HSP90AB1; linkable pd173955 analogue; bosutinib; dasatinib

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