Active Recombinant Human ACVR2B Protein, GST-tagged
Cat.No. : | ACVR2B-257H |
Product Overview : | Human ACVR2B (NP_001097.2, 161 a.a. - 512 a.a.) partial recombinant protein with GST tag expressed in baculovirus infected Sf21 cells. |
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Description : | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I (I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. Type II receptors are considered to be constitutively active kinases. This gene encodes activin A type IIB receptor, which displays a 3- to 4-fold higher affinity for the ligand than activin A type II receptor. [provided by RefSeq, Jul 2008] |
Source : | Insect Cell |
Species : | Human |
Tag : | GST |
Form : | Liquid |
Bio-activity : | The activity was determined by ELISA. The enzyme was incubated with biotinylated substrate protein, and after stopping kinase reaction by EDTA, the reaction solution was transferred into streptavidin- coated plate. Phosphorylation was detected by anti-phospho antibody and HRP-labeled anti-rabbit IgG. Substrate: ALK4 inactive mutant. ATP: 100 uM. |
Molecular Mass : | 67 kDa |
Purity : | 94 % by SDS-PAGE/CBB staining |
Applications : | Functional Study SDS-PAGE |
Storage : | Store at -80 centigrade. Aliquot to avoid repeated freezing and thawing. |
Storage Buffer : | In 50 mM Tris-HCl, 150 mM NaCl, pH 7.5 (0.1% CHAPS, 1 mM DTT, 10% glycerol) |
Protein length : | 161-512aa |
Gene Name : | ACVR2B activin A receptor, type IIB [ Homo sapiens ] |
Official Symbol : | ACVR2B |
Synonyms : | ACVR2B; activin A receptor, type IIB; activin receptor type-2B; ActR IIB; HTX4; ACTRIIB; ActR-IIB; |
Gene ID : | 93 |
mRNA Refseq : | NM_001106 |
Protein Refseq : | NP_001097 |
MIM : | 602730 |
UniProt ID : | Q13705 |
Products Types
◆ Recombinant Protein | ||
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ACVR2B-011M | Active Recombinant Mouse ACVR2B Protein, Fc-tagged | +Inquiry |
ACVR2B-275H | Recombinant Human ACVR2B Protein, His (Fc)-Avi-tagged | +Inquiry |
ACVR2B-3386C | Active Recombinant Cynomolgus ACVR2B protein(Ser28-Thr143), His-tagged | +Inquiry |
Acvr2b-296R | Recombinant Rat Acvr2b Protein, His-tagged | +Inquiry |
◆ Lysates | ||
ACVR2B-2724HCL | Recombinant Human ACVR2B cell lysate | +Inquiry |
ACVR2B-2540MCL | Recombinant Mouse ACVR2B cell lysate | +Inquiry |
ACVR2B-734CCL | Recombinant Cynomolgus ACVR2B cell lysate | +Inquiry |
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For Research Use Only. Not intended for any clinical use. No products from Creative BioMart may be resold, modified for resale or used to manufacture commercial products without prior written approval from Creative BioMart.
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