|Official Full Name||amyloid beta (A4) precursor protein|
|Background||This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]|
|Synonyms||APP; amyloid beta (A4) precursor protein; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma; amyloid beta A4 protein; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide;|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
APP involved in several pathways and played different roles in them. We selected most pathways APP participated on our site, such as Serotonergic synapse, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Serotonergic synapse||MAPK1; CYP2D9; SLC18A2; ALOX12E; GNB4; GNG11; HTR1F; MAPK3; KCND2; GABRB3|
|Alzheimers disease||NCSTN; COX8A; NDUFB8; NDUFB9; UQCRB; NDUFS4; NDUFAB1; NDUFV3; MAPK1; MAPK3|
APP has several biochemical functions, for example, DNA binding, PTB domain binding, acetylcholine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APP itself. We selected most functions APP had, and list some proteins which have the same functions with APP. You can find most of the proteins on our site.
|DNA binding||ZFP821; LMX1BA; POLE3; TDEANC2; UHRF2; EOMESB; PHC2; ZBTB44; CHD8; DMTF1|
|PTB domain binding||INSR; APP; NUP62; INPP5D|
|acetylcholine receptor binding||RIC3; RER1; KCNS1; DLG4; RAPSN; UBXN2A; JAK2; APP; NRXN1|
|enzyme binding||NOS1; HDAC10; ATF7; HIST1H2AK; NOXO1; RPA3; HAND1; SCN5A; DDX5; UGT1A1|
|growth factor receptor binding||SRC; SLC9A3R1; APP; FYN|
|heparin binding||CLEC3B; COMP; FSTL1; MSTN; ABP1; AAMP; COL13A1; THBS2; WISP1A; GREM2|
|identical protein binding||CRYAA; BNIP3L; REG3B; PRPF3; MLL1; ST13; SHANK3; MAP3K13; PFKM; ALCAMA|
|peptidase activator activity||PCOLCE2; CAV1; APP; FN1; FBLN1; PSME4B; PINK1; MMP25; PCOLCE; PSME4|
|protein binding||GTF2H2C; RARA; EFCAB12; MYO1C; HBXIP; CYFIP1; GLI1; CD27; CISD2; KIF18A|
|receptor binding||NUDT19; PLG; CTNND1; IZUMO1; HNF4A; PSPN; MPV17L; TAC3; GFRA3; ARRB2|
|serine-type endopeptidase inhibitor activity||SPINK10; PEBP1; SERPINB2; SERPINA10A; AGT; WFDC3; APPA; SPINK12; PAPLN; SERPIND1|
|transition metal ion binding||APP; APPB; APLP2; HRSP12; APPA; APLP1|
APP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APP here. Most of them are supplied by our site. Hope this information will be useful for your research of APP.