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Official Full Name amyloid beta (A4) precursor protein
Background This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Synonyms APP; amyloid beta (A4) precursor protein; AAA; AD1; PN2; ABPP; APPI; CVAP; ABETA; PN-II; CTFgamma; amyloid beta A4 protein; preA4; protease nexin-II; peptidase nexin-II; beta-amyloid peptide; alzheimer disease amyloid protein; cerebral vascular amyloid peptide;
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • E.coli
    • E.Coli or Yeast
    • HEK293
    • HEK293T
    • Human Cell
    • Mammalian Cell
    • NS0
    • Sf21 Insect Cell
    • Synthetic
    • Wheat Germ
    • Tag :
    • Fc
    • GST
    • His
    • Myc/DDK
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human APP-001H Human β-Amyloid (1-42) Synthetic N/A
    Mouse App-1666M Recombinant Mouse App Protein, Myc/DDK-tagged HEK293T Myc/DDK
    Human APP-5154H Recombinant Human APP Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Myc/DDK
    Human APP-1191H Beta - Amyloid (1 - 40) N/A
    Human APP-15839H Recombinant Human APP, His-tagged E.coli His
    Human APP-191H Recombinant Human APP, His-GST tagged E.coli Fc
    Human APP-192H Recombinant Human APP Protein, His/GST-tagged E.coli His/GST
    Human APP-243H Recombinant Human APP protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human APP-244H Recombinant Human APP protein, MYC/DDK-tagged HEK293 Myc/DDK
    Human APP-26791TH Recombinant Human APP protein, His/GST-tagged E.coli His/GST
    Human APP-27315TH Recombinant Human APP E.coli N/A
    Human APP-3087HCL Recombinant Human APP cell lysate Human Cell N/A
    Human APP-3850H Recombinant Human APP, His & GST tagged E.coli His/GST
    Human APP-526H Recombinant Human Amyloid Beta (A4) Precursor Protein, His-tagged NS0 His
    Human APP-54H Recombinant Human APP/Protease Nexin II, CF Sf21 Insect Cell His
    Human APP-586H Recombinant Human APP, Fc tagged Human Cell Fc
    Human APP-6866H Recombinant Human Amyloid Beta(A4) Precursor Protein, GST-tagged and His-tagged E.coli GST/His
    Human APP-721H Recombinant Human APP protein, GST-tagged Wheat Germ GST
    Mouse APP-1812M Recombinant Mouse APP Protein Mammalian Cell His
    Mouse App-3440M Recombinant Mouse App, His-tagged E.Coli or Yeast His
    Mouse App-5746M Recombinant Mouse App protein, His-tagged E.coli His
    Rat APP-731R Recombinant Rat APP Protein Mammalian Cell His
    Chicken APP-5881C Recombinant Chicken APP Mammalian Cell His

    APP involved in several pathways and played different roles in them. We selected most pathways APP participated on our site, such as Serotonergic synapse, Alzheimers disease, which may be useful for your reference. Also, other proteins which involved in the same pathway with APP were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Serotonergic synapse MAPK1; CYP2D9; SLC18A2; ALOX12E; GNB4; GNG11; HTR1F; MAPK3; KCND2; GABRB3

    APP has several biochemical functions, for example, DNA binding, PTB domain binding, acetylcholine receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by APP itself. We selected most functions APP had, and list some proteins which have the same functions with APP. You can find most of the proteins on our site.

    Function Related Protein
    PTB domain binding INSR; APP; NUP62; INPP5D
    acetylcholine receptor binding RIC3; RER1; KCNS1; DLG4; RAPSN; UBXN2A; JAK2; APP; NRXN1
    enzyme binding NOS1; HDAC10; ATF7; HIST1H2AK; NOXO1; RPA3; HAND1; SCN5A; DDX5; UGT1A1
    growth factor receptor binding SRC; SLC9A3R1; APP; FYN
    heparin binding CLEC3B; COMP; FSTL1; MSTN; ABP1; AAMP; COL13A1; THBS2; WISP1A; GREM2
    identical protein binding CRYAA; BNIP3L; REG3B; PRPF3; MLL1; ST13; SHANK3; MAP3K13; PFKM; ALCAMA
    peptidase activator activity PCOLCE2; CAV1; APP; FN1; FBLN1; PSME4B; PINK1; MMP25; PCOLCE; PSME4
    protein binding GTF2H2C; RARA; EFCAB12; MYO1C; HBXIP; CYFIP1; GLI1; CD27; CISD2; KIF18A
    receptor binding NUDT19; PLG; CTNND1; IZUMO1; HNF4A; PSPN; MPV17L; TAC3; GFRA3; ARRB2
    serine-type endopeptidase inhibitor activity SPINK10; PEBP1; SERPINB2; SERPINA10A; AGT; WFDC3; APPA; SPINK12; PAPLN; SERPIND1
    transition metal ion binding APP; APPB; APLP2; HRSP12; APPA; APLP1

    APP has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with APP here. Most of them are supplied by our site. Hope this information will be useful for your research of APP.

    Lee, HJ; Kwon, TY; et al. In Vitro Evaluation of Hydroxyapatite-Coated Titanium Implant with Atmospheric Plasma Treatment. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15:5593-5596(2015).
    Chuang, YT; et al. SSCLS: A Smartphone-Supported Collaborative Learning System. TELEMATICS AND INFORMATICS 32:463-474(2015).

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