CCR2
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Official Full Name
chemokine (C-C motif) receptor 2
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Overview
This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. [provided by RefSeq, Mar 2009] This gene encodes two isoforms of a receptor for monocyte chemoattractant protein-1, a chemokine which specifically mediates monocyte chemotaxis. Monocyte chemoattractant protein-1 is involved in monocyte infiltration in inflammatory diseases such as rheumatoid arthritis as well as in the inflammatory response against tumors. The receptors encoded by this gene mediate agonist-dependent calcium mobilization and inhibition of adenylyl cyclase. This gene is located in the chemokine receptor gene cluster region. Two alternatively spliced transcript variants are expressed by the gene. -
Synonyms
CCR2; chemokine (C-C motif) receptor 2; CKR2; CCR-2; CCR2A; CCR2B; CD192; CKR2A; CKR2B; CMKBR2; MCP-1-R; CC-CKR-2; C-C chemokine receptor type 2; MCP-1 receptor; monocyte chemotactic protein 1 receptor; monocyte chemoattractant protein 1 receptor; FLJ78302; MGC103828; MGC111760; MGC168006; C-C CKR-2; OTTHUMP00000209948;
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- Chicken
- Homo sapiens (Human)
- Human
- Macaca mulatta (Rhesus macaque)
- Mouse
- Mus musculus (Mouse)
- Rat
- Rattus norvegicus (Rat)
- Rhesus Monkey
- E.coli
- E.coli expression system
- HEK293
- In Vitro Cell Free System
- Mammalian Cell
- Wheat Germ
- GST
- hFc
- His
- His (Fc)
- Avi
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- N/A
- CCR2 Related Articles
- CCR2 Related Gene Family
- CCR2 Related Research Area
CCR2 involved in several pathways and played different roles in them. We selected most pathways CCR2 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CCR2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name | Pathway Related Protein |
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CCR2 has several biochemical functions, for example, . Some of the functions are cooperated with other proteins, some of the functions could acted by CCR2 itself. We selected most functions CCR2 had, and list some proteins which have the same functions with CCR2. You can find most of the proteins on our site.
Function | Related Protein |
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CCR2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CCR2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CCR2.
- Q&As
- Reviews
Q&As (6)
Ask a questionAntagonists of multiple CCR2 proteins have been developed to inhibit the binding of CCR2 to its ligand CCL2, thereby regulating the inflammatory response and migration of immune cells.
CCR2 protein plays an important role in the field of immune inflammation, and studying the function and regulatory mechanism of CCR2 protein will help the development of new drugs, for example, antagonists targeting CCR2 protein may be applied to the treatment of inflammatory diseases.
The CCR2 protein plays an important role in the migration and activation of macrophages and may therefore be involved in the initiation and progression of infectious diseases.
There are no specific diagnostic methods for the CCR2 protein, but the CCR2 protein could be a potential candidate for inflammatory markers.
By binding to its ligand CCL2, CCR2 protein regulates the release of inflammatory mediators, the migration of immune cells, and the occurrence of inflammatory responses.
CCR2 protein plays an important role in the activation and migration of immune cells, so it can be used in immune vaccine design to promote immune cell infiltration and antigen presentation.
Customer Reviews (3)
Write a reviewThis reproducibility of CCR2 was very good, showing good production process and quality control.
I appreciate the attention paid to product quality by the producers of CCR2, and their product is very stable, which makes our experiments smoother.
The bands of CCR2 in Western blot were regular in shape and showed good quality.
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