cd163
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  • Official Full Name
  • CD163 Molecule
  • Background
  • CD163 (Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
  • Synonyms
  • M130; MM130; scavenger receptor cysteine-rich type 1 protein M130; OTTHUMP00000238617; OTTHUMP00000238618; CD163 Molecule; OTTHUMP00000238619; OTTHUMP00000238620; hemoglobin scavenger receptor; macrophage-associated antigen; CD163
Cat.#:CD163-1022MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse CD163 Protein (86-365 aa), His-tagged
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Cat.#:CD163-1667MTag:His
Source (Host):YeastSpecies:Mouse
Product nameRecombinant Mouse CD163 Protein (86-365 aa), His-tagged
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Cat.#:CD163-356HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD163 Protein, His-tagged
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Cat.#:CD163-0726HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CD163 Protein, GST-Tagged
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Cat.#:CD163-10910HTag:GST
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD163, GST-tagged
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Cat.#:CD163-112HTag:His
Source (Host):NS0Species:Human
Product nameRecombinant Human CD163, His-tagged
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Cat.#:CD163-27220THTag:
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CD163
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Cat.#:CD163-4272HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CD163, His-tagged
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Cat.#:CD163-510HTag:His
Source (Host):NSO cellsSpecies:Human
Product nameRecombinant Human CD163, His-tagged
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Cat.#:Cd163-1849MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd163 protein, His-tagged
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Cat.#:Cd163-371MTag:His
Source (Host):NSO cellsSpecies:Mouse
Product nameRecombinant Mouse Cd163, His-tagged
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Cat.#:Cd163-1850RTag:His/T7
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cd163 protein, His & T7-tagged
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Cat.#:CD163-94PTag:N/A
Source (Host):E. coliSpecies:Pig
Product nameRecombinant Porcine CD163
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Cat.#:CD163-7683HCLTag:
Source (Host):Species:Human
Product nameRecombinant Human CD163 293 Cell Lysate
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Involved Pathway

CD163 involved in several pathways and played different roles in them. We selected most pathways CD163 participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD163 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Binding and Uptake of Ligands by Scavenger Receptors
SCGB3A2; IGKV1-5; COL1A1; HSPH1; HPX; COL3A1; COL1A2; APOBB.1; AMBP; CD163
Scavenging of heme from plasma
LOC479668; HPX; HP; CD163; NFX1; AMBP
Vesicle-mediated transport
TRAPPC6B; MYO6B; TRAPPC10; TRAPPC2; FTH1B; CNO; MIA3; DTNBP1; SEC16B; PLDN

Protein Function

CD163 has several biochemical functions, for example, protein binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD163 itself. We selected most functions CD163 had, and list some proteins which have the same functions with CD163. You can find most of the proteins on our site.
Function
Related Protein
Function protein binding
Related Protein SYT2; SCHIP1; UBE2O; RHOC; NABP1; ELF3; NFKB2; ZMAT2; HDDC2; WNT3A
Function scavenger receptor activity
Related Protein SCARF1; LGALS3BPA; TMPRSS4; COLEC12; SRCRB4D; LOXL3A; CD163; TMPRSS4B; TINAGL1; CXCR7

Interacting Protein

CD163 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD163 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD163.
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CD163 Related Articles

Ong, CB; Brandenberger, C; et al. Immunohistochemical Characterization and Morphometric Analysis of Macrophages in Rat Mammary Tumors. VETERINARY PATHOLOGY 52:414-418(2015).
Theate, I; van Baren, N; et al. Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues. CANCER IMMUNOLOGY RESEARCH 3:161-172(2015).