CD163 Protein, CD163 Molecule

CD163

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CD163

Official Full Name CD163 Molecule
Background CD163 (Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.
Synonyms M130; MM130; scavenger receptor cysteine-rich type 1 protein M130; OTTHUMP00000238617; OTTHUMP00000238618; CD163 Molecule; OTTHUMP00000238619; OTTHUMP00000238620; hemoglobin scavenger receptor; macrophage-associated antigen; CD163
    • Species :
    • Human
    • Mouse
    • Pig
    • Rat
    • Source :
    • E.coli
    • HEK293
    • NS0
    • Wheat Germ
    • Yeast
    • Tag :
    • GST
    • His
    • T7
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse CD163-1022M Recombinant Mouse CD163 Protein (86-365 aa), His-tagged E.coli His
    Mouse CD163-1667M Recombinant Mouse CD163 Protein (86-365 aa), His-tagged Yeast His
    Human CD163-356H Recombinant Human CD163 protein, His-tagged HEK293 His
    Human CD163-0726H Recombinant Human CD163 Protein, GST-Tagged Wheat Germ GST
    Human CD163-10910H Recombinant Human CD163, GST-tagged E.coli GST
    Human CD163-112H Recombinant Human CD163, His-tagged NS0 His
    Human CD163-27220TH Recombinant Human CD163 Wheat Germ N/A
    Human CD163-4272H Recombinant Human CD163, His-tagged E.coli His
    Human CD163-510H Recombinant Human CD163, His-tagged NS0 His
    Human CD163-7683HCL Recombinant Human CD163 293 Cell Lysate HEK293 N/A
    Mouse Cd163-1849M Recombinant Mouse Cd163 protein, His-tagged E.coli His
    Mouse Cd163-371M Recombinant Mouse Cd163, His-tagged NS0 His
    Rat Cd163-1850R Recombinant Rat Cd163 protein, His & T7-tagged E.coli His/T7
    Pig CD163-94P Recombinant Porcine CD163 E.coli N/A

    CD163 involved in several pathways and played different roles in them. We selected most pathways CD163 participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD163 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Binding and Uptake of Ligands by Scavenger Receptors APOA1B; Alb; IGKV1-5; COL3A1; AMBP; IGLC2; CD163; HSPH1; STAB2; COL1A2
    Scavenging of heme from plasma AMBP; LOC479668; HP; NFX1; HPX; CD163
    Vesicle-mediated transport FTH1B; PICALM; TRAPPC2; AP1S3A; TPD52L1; RALAA; AMBP; GJA8; TRAPPC10; SNX9B

    CD163 has several biochemical functions, for example, protein binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD163 itself. We selected most functions CD163 had, and list some proteins which have the same functions with CD163. You can find most of the proteins on our site.

    Function Related Protein
    protein binding DNAJC11; SLC39A13; ZWINT; FAM104A; PDXP; ZFP423; PDE6D; TIE1; ELK1; PTPN4
    scavenger receptor activity SUSD2; PRSS7; VTNB; C8orf84; TMPRSS4; LOXL4; TMPRSS3; TINAGL1; CD5L; PRG4B

    CD163 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD163 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD163.

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    Ong, CB; Brandenberger, C; et al. Immunohistochemical Characterization and Morphometric Analysis of Macrophages in Rat Mammary Tumors. VETERINARY PATHOLOGY 52:414-418(2015).
    Theate, I; van Baren, N; et al. Extensive Profiling of the Expression of the Indoleamine 2,3-Dioxygenase 1 Protein in Normal and Tumoral Human Tissues. CANCER IMMUNOLOGY RESEARCH 3:161-172(2015).

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