|Official Full Name||CD163 Molecule|
|Background||CD163 (Cluster of Differentiation 163) is a human protein encoded by the CD163 gene. Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron, via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization, inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells. After shedding, the soluble form (sCD163) may play an anti-inflammatory role, and may be a valuable diagnostic parameter for monitoring macrophage activation in inflammatory conditions.|
|Synonyms||M130; MM130; scavenger receptor cysteine-rich type 1 protein M130; OTTHUMP00000238617; OTTHUMP00000238618; CD163 Molecule; OTTHUMP00000238619; OTTHUMP00000238620; hemoglobin scavenger receptor; macrophage-associated antigen; CD163|
|Species||Cat.#||Product name||Source (Host)||Tag||Protein Length||Price|
CD163 involved in several pathways and played different roles in them. We selected most pathways CD163 participated on our site, such as Binding and Uptake of Ligands by Scavenger Receptors, Scavenging of heme from plasma, Vesicle-mediated transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD163 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
|Pathway Name||Pathway Related Protein|
|Binding and Uptake of Ligands by Scavenger Receptors||APOA1B; Alb; IGKV1-5; COL3A1; AMBP; IGLC2; CD163; HSPH1; STAB2; COL1A2|
|Scavenging of heme from plasma||AMBP; LOC479668; HP; NFX1; HPX; CD163|
|Vesicle-mediated transport||FTH1B; PICALM; TRAPPC2; AP1S3A; TPD52L1; RALAA; AMBP; GJA8; TRAPPC10; SNX9B|
CD163 has several biochemical functions, for example, protein binding, scavenger receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD163 itself. We selected most functions CD163 had, and list some proteins which have the same functions with CD163. You can find most of the proteins on our site.
|protein binding||DNAJC11; SLC39A13; ZWINT; FAM104A; PDXP; ZFP423; PDE6D; TIE1; ELK1; PTPN4|
|scavenger receptor activity||SUSD2; PRSS7; VTNB; C8orf84; TMPRSS4; LOXL4; TMPRSS3; TINAGL1; CD5L; PRG4B|
CD163 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD163 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD163.