CD74 Protein, CD74 molecule, major histocompatibility complex, class II invariant chain

CD74

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CD74

Official Full Name CD74 molecule, major histocompatibility complex, class II invariant chain
Background The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
Synonyms CD74; CD74 molecule, major histocompatibility complex, class II invariant chain; II; DHLAG; HLADG; Ia-GAMMA; HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated);
    • Species :
    • Chicken
    • Human
    • Mouse
    • Rat
    • Source :
    • CHO
    • E.coli
    • HEK293
    • Human Cell
    • Insect Cell
    • Mammalian Cell
    • Wheat Germ
    • Tag :
    • GST
    • HA
    • His
    • T7
    • Myc
    • DDK
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Human CD74-114H Recombinant Human CD74, His-tagged Insect Cell His
    human CD74-2227H Recombinant human CD74 protein, His-tagged HEK293 His
    Human CD74-2228H Recombinant Human CD74, Myc-DDK-Tagged HEK293 Myc/DDK
    Human CD74-2229H Recombinant Human CD74 Wheat Germ N/A
    Human CD74-2230H Recombinant Human CD74, GST-Tagged Wheat Germ GST
    Human CD74-2231H Recombinant Human CD74, Hemagglutinin-tagged CHO N/A
    Human CD74-2232H Recombinant Human CD74, HA-tagged CHO HA
    Human CD74-2603HCL Recombinant Human CD74 cell lysate Human Cell N/A
    Human CD74-546H Recombinant Human CD74 Protein, HA-tagged CHO HA
    Human CD74-589H Recombinant Human CD74 molecule, major histocompatibility complex, class II invariant chain, His-tagged E.coli His
    Mouse Cd74-1157M Recombinant Mouse Cd74 Protein, His-tagged E.coli His
    Mouse Cd74-641M Recombinant Mouse Cd74 Protein, HA-tagged CHO HA
    Mouse Cd74-6871M Recombinant Mouse Cd74 protein, His & T7-tagged E.coli His/T7
    Mouse CD74-9493M Recombinant Mouse CD74, His-tagged HEK293 His
    Rat CD74-1262R Recombinant Rat CD74 Protein Mammalian Cell His
    Rat Cd74-6872R Recombinant Rat Cd74 protein, His & GST-tagged E.coli His/GST
    Chicken CD74-1132C Recombinant Chicken CD74 Mammalian Cell His

    CD74 involved in several pathways and played different roles in them. We selected most pathways CD74 participated on our site, such as Antigen processing and presentation, Tuberculosis, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD74 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Antigen processing and presentation HSP90AB1; TAP1; HLA-DPA1; HLA-DQB1; HSPA5; TNF; HSP90AA1; HLA-DQA2; H2-Q10; CANX
    Tuberculosis RFXANK; IFNA7; TLR9; BAX; CD74; MAPK13; SPHK1; CD209A; PPP3CA; FCGR1
    Herpes simplex infection ALYREF; STAT1A; Ifna15; NXF1; FASLG; IFNAR2; HLA-DQA2; TLR9; TAP1; TRP53

    CD74 has several biochemical functions, for example, MHC class II protein binding, MHC class II protein binding, via antigen binding groove, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD74 itself. We selected most functions CD74 had, and list some proteins which have the same functions with CD74. You can find most of the proteins on our site.

    Function Related Protein
    MHC class II protein binding CD74; MARCH8; KRT17; CD74A; CD4; LAG3; CD74B
    MHC class II protein binding, via antigen binding groove CD74
    MHC class II protein complex binding MS4A1; HSPA8; HLA-DMA; YWHAE; HSP90AB1; HLA-DOB; CD81; ANXA11; ATP1B1; HSP90AA1
    beta-amyloid binding APOE; APBA3; BCHE; CLSTN1; OLFM1; CD74; IDE; APOEA; APBA2; TM2D1
    cytokine binding ELANE; KITA; CD74; TNFRSF11A; NRP2; GBP1; KITB; KIT; PARK7; CXCR4
    cytokine receptor activity LIFRB; CRFB17; GHR; CRFB12; IL2RGB; IRX1; CRFB15; F3B; Il6ra; CSF3R
    identical protein binding RIPK3; PFKL; CEACAM5; TP63; REG3B; SQSTM1; DYRK1A; ROBO2; PRPS2; GRB2
    macrophage migration inhibitory factor binding CD74
    nitric-oxide synthase binding DNM2; SLC6A4; CALM2; NOS1AP; ATP2B4; CALM1; CAV1; DMD; SLC14A2; CAV3
    protein binding SKA1; STON2; KRTAP3-2; PSENEN; ZNF143; CATSPERG2; ANKRD45; CBX4; VPS72; NDEL1
    protein binding involved in protein folding PDCL3; PFDN1; CALR; HSPA1B; PFDN2; HSPA1A; CD74; CALR3; RIC3; CLGN

    CD74 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD74 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD74.

    HLA-DQA1; CXCR4; UBA1; UBE2N; UBE2V1; Map3k1; HLA-DRA; HLA-DPA1; yopM; HADHA; ltp_ebvg; yegQ; q5nem9_fratt; q5nes9_fratt; dnaJ2; hemL

    Zou, HLY; Li, QH; et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3493-3498(2015).
    Setti, SE; Littlefield, AM; et al. Diet-induced obesity attenuates endotoxin-induced cognitive deficits. PHYSIOLOGY & BEHAVIOR 141:1-8(2015).

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