cd74
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  • Official Full Name
  • CD74 molecule, major histocompatibility complex, class II invariant chain
  • Background
  • The protein encoded by this gene associates with class II major histocompatibility complex (MHC) and is an important chaperone that regulates antigen presentation for immune response. It also serves as cell surface receptor for the cytokine macrophage migration inhibitory factor (MIF) which, when bound to the encoded protein, initiates survival pathways and cell proliferation. This protein also interacts with amyloid precursor protein (APP) and suppresses the production of amyloid beta (Abeta). Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2011]
  • Synonyms
  • CD74; CD74 molecule, major histocompatibility complex, class II invariant chain; II; DHLAG; HLADG; Ia-GAMMA; HLA class II histocompatibility antigen gamma chain; p33; HLA-DR-gamma; MHC HLA-DR gamma chain; Ia-associated invariant chain; gamma chain of class II antigens; HLA-DR antigens-associated invariant chain; CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated);
Cat.#:Cd74-1157MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd74 Protein, His-tagged
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Cat.#:CD74-114HTag:His
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human CD74, His-tagged
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Cat.#:CD74-2227HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD74, His tagged
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Cat.#:CD74-2228HTag:MYC/DDK
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD74, Myc-DDK-Tagged
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Cat.#:CD74-2229HTag:N/A
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CD74
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Cat.#:CD74-2230HTag:GST
Source (Host):Wheat germSpecies:Human
Product nameRecombinant Human CD74, GST-Tagged
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Cat.#:CD74-2231HTag:
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD74, Hemagglutinin-tagged
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Cat.#:CD74-2232HTag:HA
Source (Host):CHOSpecies:Human
Product nameRecombinant Human CD74, HA-tagged
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Cat.#:CD74-546HTag:HA
Source (Host):CHO CellsSpecies:Human
Product nameRecombinant Human CD74 Protein, HA-tagged
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Cat.#:Cd74-641MTag:HA
Source (Host):CHO CellsSpecies:Mouse
Product nameRecombinant Mouse Cd74 Protein, HA-tagged
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Cat.#:Cd74-6871MTag:His/T7
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Cd74 protein, His & T7-tagged
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Cat.#:CD74-9493MTag:His
Source (Host):HEK293Species:Mouse
Product nameRecombinant Mouse CD74, His-tagged
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Cat.#:CD74-1262RTag:His
Source (Host):Mammalian CellsSpecies:Rat
Product nameRecombinant Rat CD74 Protein
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Cat.#:Cd74-6872RTag:His/GST
Source (Host):E. coliSpecies:Rat
Product nameRecombinant Rat Cd74 protein, His & GST-tagged
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Cat.#:CD74-1132CTag:His
Source (Host):Mammalian CellsSpecies:Chicken
Product nameRecombinant Chicken CD74
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Cat.#:CD74-2603HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CD74 cell lysate
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Involved Pathway

CD74 involved in several pathways and played different roles in them. We selected most pathways CD74 participated on our site, such as Antigen processing and presentation, Tuberculosis, Herpes simplex infection, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD74 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Antigen processing and presentation
KIR2DS5; KLRC2; HLA-DRB1; HLA-DRB3; HSPA1L; CTSS; CANX; RFXAP; HLA-B; HSP90AA1
Tuberculosis
CARD9; Ifna11; IFNA7; IL10RA; MYD88; AKT2; FCGR4; IL6; IFNG; HLA-DMA
Herpes simplex infection
TLR2; CLOCKB; TAP2; C5; HLA-DQB1; SKP1; HLA-F; CFP; HLA-DRB5; TRAF5

Protein Function

CD74 has several biochemical functions, for example, MHC class II protein binding, MHC class II protein binding, via antigen binding groove, MHC class II protein complex binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CD74 itself. We selected most functions CD74 had, and list some proteins which have the same functions with CD74. You can find most of the proteins on our site.
Function
Related Protein
Function MHC class II protein binding
Related Protein CD74; KRT17; LAG3; CD4; MARCH8; CD74B; CD74A
Function MHC class II protein binding, via antigen binding groove
Related Protein CD74
Function MHC class II protein complex binding
Related Protein HLA-DRB1; CD74; HLA-DMB; ANXA11; HSP90AB1; HLA-DOA; CD81; HLA-DMA; PKM2; HLA-DOB
Function beta-amyloid binding
Related Protein FBXO2; NGFR; LDLRAP1; PION; BCHE; BACE2; APBB1; CST3; COL25A1; OLFM1
Function cytokine binding
Related Protein ELANE; CD74; CSF1R; CNTFR; LIFR; PARK7; NRP1; TNFRSF11A; CXCR4; CHRD
Function cytokine receptor activity
Related Protein IL20RA; IL12B; IL28RA; IL17RB; Il6ra; CRFB2; IL2RGA; PRLRA; CRFB4; IL13RA1
Function identical protein binding
Related Protein STK10; GM5077; KCTD17; SEPHS1; GBP5; IFI203; SMURF2; SORD; MSTN; AIM2
Function macrophage migration inhibitory factor binding
Related Protein CD74
Function nitric-oxide synthase binding
Related Protein CDH2; CALM1; CAV1; ATP2B4; CAMK2D; DMD; CALM3; SNTA1; CAV3; ACTB
Function protein binding
Related Protein FOXR1; ZFAND2B; GEMIN6; PPP1R2P9; CYP2S1; TNFRSF14; SOS1; MALSU1; PNOC; CRLF1
Function protein binding involved in protein folding
Related Protein PFDN1; DNAJB8; CD74; PDCL3; RIC3; CLGN; PFDN2; CALR3; HSPA1A; HSPA1B

Interacting Protein

CD74 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD74 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD74.
HLA-DQA1; CXCR4; UBA1; UBE2N; UBE2V1; Map3k1; HLA-DRA; HLA-DPA1; yopM; HADHA; ltp_ebvg; yegQ; q5nem9_fratt; q5nes9_fratt; dnaJ2; hemL

CD74 Related Articles

Zou, HLY; Li, QH; et al. PF-06463922 is a potent and selective next-generation ROS1/ALK inhibitor capable of blocking crizotinib-resistant ROS1 mutations. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 112:3493-3498(2015).
Setti, SE; Littlefield, AM; et al. Diet-induced obesity attenuates endotoxin-induced cognitive deficits. PHYSIOLOGY & BEHAVIOR 141:1-8(2015).