ceacam5
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  • Official Full Name
  • carcinoembryonic antigen-related cell adhesion molecule 5
  • Background
  • CEACAM1 and CEACAM5 belong to the carcinoembryonic antigen (CEA) gene family. It is expressed on cells of epithelial and myeloid origin. CEACAM1 expression is downregulated in many tumors indicating a tumor - suppressive function. The antitumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of antiangiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM. CEACAM5 is a cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. CEACAM5 is a homodimer. It is a receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
  • Synonyms
  • CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100; DKFZp781M2392
Cat.#:CEACAM5-3257MTag:Fc
Source (Host):HEK293 CellsSpecies:Mouse
Product nameRecombinant Mouse CEACAM5 Protein, Fc-tagged
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Cat.#:CEACAM5-1025CTag:His
Source (Host):HEK293Species:Cynomolgus
Product nameRecombinant Cynomolgus CEACAM5 Protein (Met1-Ala688), His-tagged
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Cat.#:CEACAM5-494HTag:HIgG1 Fc
Source (Host):HEK293Species:Human
Product nameRecombinant Human CEACAM5 Protein (Met1-Ala685), HIgG1 Fc-tagged
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Cat.#:CEACAM5-495HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CEACAM5 Protein (Met1-Ala685), His-tagged, Biotinylated
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Cat.#:CEACAM5-665HATag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CEACAM5 protein, Fc-His-tagged, APC labeled
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Cat.#:CEACAM5-665HPTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CEACAM5 protein, Fc-His-tagged, R-PE labeled
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Cat.#:CEACAM5-1095HTag:GST
Source (Host):Wheat GermSpecies:Human
Product nameRecombinant Human CEACAM5 Protein, GST-Tagged
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Cat.#:CEACAM5-3190HTag:DDK
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CEACAM5 Protein, DDK-tagged
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Cat.#:CEACAM5-111HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CEACAM5 Protein, His-tagged
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Cat.#:CEACAM5-112HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CEACAM5 Protein, His-tagged
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Cat.#:CEACAM5-113HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CEACAM5 Protein, His-tagged
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Cat.#:CEACAM5-114HTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CEACAM5 Protein, His-tagged
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Cat.#:CEACAM5-185HTag:
Source (Host):Insect cellsSpecies:Human
Product nameRecombinant Human CEACAM5 protein
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Cat.#:CEACAM5-27800THTag:His
Source (Host):E. coliSpecies:Human
Product nameRecombinant Human CEACAM5 protein, His-tagged
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Cat.#:CEACAM5-3200HTag:His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CEACAM5, His tagged
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Cat.#:CEACAM5-517HTag:His
Source (Host):HEK293FSpecies:Human
Product nameRecombinant Human CEACAM5 protein, His-tagged
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Cat.#:CEACAM5-665HTag:FC/His
Source (Host):HEK293Species:Human
Product nameRecombinant Human CEACAM5, Fc-His tagged
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Cat.#:Ceacam5-115MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ceacam5 Protein, His-tagged
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Cat.#:Ceacam5-116MTag:His
Source (Host):E. coliSpecies:Mouse
Product nameRecombinant Mouse Ceacam5 Protein, His-tagged
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Cat.#:CEACAM5-805RTag:His
Source (Host):Mammalian CellsSpecies:Rhesus Macaque
Product nameRecombinant Rhesus monkey CEACAM5 Protein, His-tagged
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Cat.#:CEACAM5-1201HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Carcinoembryonic Antigen-related Cell Adhesion Molecule 5
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Cat.#:CEACAM5-1203HTag:N/A
Source (Host):Baculovirus-Insect CellsSpecies:Human
Product nameRecombinant Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5
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Cat.#:CEACAM5-27803THTag:N/A
Source (Host):Human liverSpecies:Human
Product nameNative Human CEACAM5
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Cat.#:CEACAM5-2238HCLTag:
Source (Host):HEK293Species:Human
Product nameRecombinant Human CEACAM5 cell lysate
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Cat.#:CEACAM5-186HTag:
Source (Host):Species:Human
Product nameHuman Carcinoembryonic Antigen Reference standard
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Protein Function

CEACAM5 has several biochemical functions, for example, GPI anchor binding, identical protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CEACAM5 itself. We selected most functions CEACAM5 had, and list some proteins which have the same functions with CEACAM5. You can find most of the proteins on our site.
Function
Related Protein
Function GPI anchor binding
Related Protein DPEP1; VNN1; MPPE1; THY1; CEACAM5; NIPAL1
Function identical protein binding
Related Protein PRKD1; PTK6; PYDC3; UHRF1; CLDN16; CDC42BPA; KCTD17; ALCAMA; VWA1; PLK4
Function protein homodimerization activity
Related Protein LMLN; ATG7; SLK; ABCD1; NETO2; CLIC6; ZFP652; ASNSD1; GIPC1; MIXL1

Interacting Protein

CEACAM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEACAM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CEACAM5.
c3; llama single domain; draE; CEACAM1; CEACAM6; afaE3; UQCC2

CEACAM5 Related Articles

Wakabayashi-Nakao, K; Hatakeyama, K; et al. Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma cells. BIOMEDICAL RESEARCH-TOKYO 35:237-242(2014).
Bajenova, O; Chaika, N; et al. Carcinoembryonic antigen promotes colorectal cancer progression by targeting adherens junction complexes. EXPERIMENTAL CELL RESEARCH 324:115-123(2014).