CEACAM5 Protein, carcinoembryonic antigen-related cell adhesion molecule 5

CEACAM5

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CEACAM5

Official Full Name carcinoembryonic antigen-related cell adhesion molecule 5
Background CEACAM1 and CEACAM5 belong to the carcinoembryonic antigen (CEA) gene family. It is expressed on cells of epithelial and myeloid origin. CEACAM1 expression is downregulated in many tumors indicating a tumor - suppressive function. The antitumor effect may be due to inhibition of tumor angiogenesis, possibly by increased secretion of antiangiogenic molecules from the cells. Like all members of the CEACAM family, it consists of a single N domain, with structural homology to the immunoglobulin variable domains, followed by two immunoglobulin constant-like A (A1, A2) and one B domain. While the N, A1 and B domains can also be found in other CEA-family members, the A2 domain of CEACAM1 differs from those found in other CEACAM. CEACAM5 is a cell surface glycoprotein that plays a role in cell adhesion and in intracellular signaling. CEACAM5 is a homodimer. It is a receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer. Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.
Synonyms CEACAM5; carcinoembryonic antigen-related cell adhesion molecule 5; CEA; CD66e; meconium antigen 100; DKFZp781M2392
    • Species :
    • Cynomolgus
    • Human
    • Mouse
    • Rhesus Macaque
    • Source :
    • E.coli
    • HEK293
    • HEK293 Cells
    • HEK293F
    • Human Cell
    • Human Liver Metastasis of Colon Adenocarcinoma
    • Insect Cell
    • Mammalian Cell
    • Sf9 Insect Cell
    • Wheat Germ
    • Tag :
    • DDK
    • Fc
    • His
    • GST
    • HIgG1 Fc
    • His & Avi
    • N/A
    Species Cat.# Product name Source (Host) Tag Protein Length Price
    Mouse CEACAM5-3257M Recombinant Mouse CEACAM5 Protein, Fc-tagged HEK293 Cells Fc
    Cynomolgus CEACAM5-1025C Recombinant Cynomolgus CEACAM5 Protein (Met1-Ala688), His-tagged HEK293 His
    Human CEACAM5-494H Recombinant Human CEACAM5 Protein (Met1-Ala685), HIgG1 Fc-tagged HEK293 HIgG1 Fc
    Human CEACAM5-495H Recombinant Human CEACAM5 Protein (Met1-Ala685), His-tagged, Biotinylated HEK293 His
    Human CEACAM5-665HA Recombinant Human CEACAM5 protein, Fc-His-tagged, APC labeled HEK293 Fc/His
    Human CEACAM5-665HP Recombinant Human CEACAM5 protein, Fc-His-tagged, R-PE labeled HEK293 Fc/His
    Human CEACAM5-87H Recombinant Human CEACAM5 Protein, His & Avi-Tagged HEK293 His & Avi
    Human CEACAM5-1095H Recombinant Human CEACAM5 Protein, GST-Tagged Wheat Germ GST
    Human CEACAM5-111H Recombinant Human CEACAM5 Protein, His-tagged E.coli His
    Human CEACAM5-112H Recombinant Human CEACAM5 Protein, His-tagged E.coli His
    Human CEACAM5-113H Recombinant Human CEACAM5 Protein, His-tagged E.coli His
    Human CEACAM5-114H Recombinant Human CEACAM5 Protein, His-tagged E.coli His
    Human CEACAM5-1201H Recombinant Human Carcinoembryonic Antigen-related Cell Adhesion Molecule 5 Sf9 Insect Cell N/A
    Human CEACAM5-1203H Recombinant Human Carcinoembryonic Antigen-Related Cell Adhesion Molecule 5 Insect Cell N/A
    Human CEACAM5-185H Recombinant Human CEACAM5 protein Insect Cell N/A
    Human CEACAM5-186H Human Carcinoembryonic Antigen Reference standard N/A
    Human CEACAM5-2238HCL Recombinant Human CEACAM5 cell lysate Human Cell N/A
    Human CEACAM5-27800TH Recombinant Human CEACAM5 protein, His-tagged E.coli His
    Human CEACAM5-27803TH Native Human CEACAM5 Human Liver Metastasis of Colon Adenocarcinoma N/A
    Human CEACAM5-3190H Recombinant Human CEACAM5 Protein, DDK-tagged Insect Cell DDK
    Human CEACAM5-3200H Recombinant Human CEACAM5, His tagged Human Cell His
    Human CEACAM5-517H Recombinant Human CEACAM5 protein, His-tagged HEK293F His
    Human CEACAM5-665H Recombinant Human CEACAM5, Fc-His tagged Human Cell Fc/His
    Mouse Ceacam5-115M Recombinant Mouse Ceacam5 Protein, His-tagged E.coli His
    Mouse Ceacam5-116M Recombinant Mouse Ceacam5 Protein, His-tagged E.coli His
    Rhesus Macaque CEACAM5-805R Recombinant Rhesus monkey CEACAM5 Protein, His-tagged Mammalian Cell His

    CEACAM5 involved in several pathways and played different roles in them. We selected most pathways CEACAM5 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with CEACAM5 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein

    CEACAM5 has several biochemical functions, for example, GPI anchor binding, identical protein binding, protein homodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CEACAM5 itself. We selected most functions CEACAM5 had, and list some proteins which have the same functions with CEACAM5. You can find most of the proteins on our site.

    Function Related Protein
    GPI anchor binding MPPE1; DPEP1; THY1; CEACAM5; VNN1; NIPAL1
    identical protein binding CEP57L1; MYBPC3; CLDN10; SH3GL3; MCM6; TP73; ATG101; ADORA2A; DYNLT1A; SCAND1
    protein homodimerization activity GLA; TG; WHRN; PVRL1A; TSG101; SQSTM1; PYCARD; TESC; CADM3; WRN

    CEACAM5 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CEACAM5 here. Most of them are supplied by our site. Hope this information will be useful for your research of CEACAM5.

    c3; llama single domain; draE; CEACAM1; CEACAM6; afaE3; UQCC2

    Wakabayashi-Nakao, K; Hatakeyama, K; et al. Carcinoembryonic antigen-related cell adhesion molecule 4 (CEACAM4) is specifically expressed in medullary thyroid carcinoma cells. BIOMEDICAL RESEARCH-TOKYO 35:237-242(2014).
    Bajenova, O; Chaika, N; et al. Carcinoembryonic antigen promotes colorectal cancer progression by targeting adherens junction complexes. EXPERIMENTAL CELL RESEARCH 324:115-123(2014).

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